Normal cell development and prevention of tumor formation rely on the tumor-suppressor protein p53. This crucial protein is produced from the Tp53 gene, which encodes the p53 protein. The p53 protein plays a vital role in regulating cell growth, DNA repair, and apoptosis (programmed cell death)...
The p53 gene (generic name used here, also known as TP53 in humans and Trp53 in mouse) encodes the tumour suppressor protein p53 (TP53/TRP53), a transcription factor that can regulate diverse cellular processes, including apoptotic cell death, adaptation of cellular metabolism, cell cycle arrest...
TP53gene mutations and aneuploidy in cancer Several large-scale cancer genome analyses showed that of all common oncogenic mutations, aneuploidy most strongly correlates with mutations in theTP53gene (Taylor et al.2018; Donehower et al.2019; Hoadley et al.2014; Ciriello et al.2013; Davoli et al...
Autophagy occurs by forming a dual-layered vesicle known as the autophagosome, which envelops the cytoplasmic contents to be broken down. Afterwards, the autophagosome combines with lysosomes, resulting in the formation of the autolysosome, where the load is degraded by lysosomal hydrolases. Finally, ...
Likewise, oncogenes and tumor suppressors are linked to the regulation of glucose metabolism in cancer cells [8]. The expression of TP53- inducible glycolysis and apoptosis regulator (TIGAR) is upregulated by the wild-type tumor suppressor ...
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas Cell Rep., 28 (2019), pp. 1370-1384.e5 View PDFView articleView in ScopusGoogle Scholar Drost et al., 2015 J. Drost, R.H. van Jaarsveld, B. Ponsioen, C. Zimberlin, R. van Boxtel, A. Buijs, N....
. The mutation/deletion ofTP53was soon demonstrated in many common tumor types (Nigroet al., 1989), and the cancerprone Li-Fraumeni Syndrome, which is characterized by a familial clustering of early (< 45 years) onset tumors, was found to be caused by germline mutations in theTP53gene (...
MicroRNAs (miRNAs) are small RNA molecules of approximately 22 nucleotides that bind to the 3′-untranslated region (3′-UTR) of the target mRNA and negatively regulate the expression of the target gene at the transcriptional level [8]. miRNAs mainly participate in the pathogenesis of AML throug...
Here we review the recent findings to elucidate the important role of p53 in cell metabolism. Keywords: tumor suppressor 53; glycolysis; oxidative phosphorylation; TP53-induced glycolysis regulator; damage-regulated autophagy modulator Acta Pharmacologica Sinica (2010) 31: 1208–1212; doi: 10.1038/aps...
In addition, the correlation between AAG clusters and the clinical information of NSCLC patients was explored, and differences in biological functions between AAG clusters were compared by gene set enrichment analysis (GSEA). Construction and biological function analysis of the ceRNA network...