TP53is a gene found onchromosome 17that codes for a 53-kDa protein involved in various aspects of the cell cycle, including cell death, response of cells to DNA damage, differentiation, and vascular phenomena. It is generally thought thatTP53mutations are found more frequently in secondaryglioblas...
摘要 Pancreatic cancer is a malignant form of cancer with one of the worst prognoses. The poor prog nosis and resistance to therapeutic modalities have been linked to TP53 mutation. Pathological examinations, such as biopsies, cannot be frequently performed in clinical practice; therefore, noninvasive...
Full Name TP53 regulating kinase Synonyms BUD32, C20orf64, dJ101A2, Nori 2, Nori 2p, p53 related protein kinase, PRPK, TP53 regulating kinase, TP53RK Calculated Molecular Weight 28 kDa Observed Molecular Weight 30 kDa GenBank Accession Number BC009727 Gene Symbol TP53RK Gene ID (NCBI) 11285...
Tumor protein 53 (TP53) is the most frequently mutated gene in human cancer, typically occurring as a multihit process with a point mutation in one allele and loss of the other wild-type (WT) allele1,2.TP53mutations are also strongly associated with copy number alterations (CNA) and structu...
TP53is a tumor suppressor gene involved in multiple cellular processes that coordinate DNA damage response [1]. SomaticTP53pathogenic variants (PVs) occur in most tumor types, and when present in the germline, they cause an autosomal dominant cancer susceptibility condition called Li-Fraumeni syndrome...
Original antibody is raised against recombinant protein corresponding to full length human TP53. Reactivity Human Form Liquid Purification Affinity-chromatography Isotype IgG Recommend Usage ELISA Immunohistochemistry (1:50-1:200) Immunofluorescence(1:20-1:200) ...
The status of TP53 as a tumor suppressor gene can be used as a paradigm. Wild-type TP53 clearly acts as a negative regulator of cell growth, but considering TP53 mutations solely as LOF mutations would prevent a full understanding of how TP53 mutations drive tumor growth, as TP53 status in...
CRISPR-based methods, which introduceTP53variants directly into the endogenous gene locus, provide a more physiological and comprehensive insight into their functions. Recent proof-of-principle studies using CRISPR base or prime editing show promise but still face challenges in achieving full coverage of...
If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. Physical form【外形】 Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol 产品性质 biological source【生物来源】 rabbit Quality Level【质量水平】 ...
OncoTargets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article Original Research Association between TP53 gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population This article was published in the following Dove Press journal: OncoTargets ...