Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable attention has also been devoted to understanding how TP53 regulates metabolic programming of the cell, focusing on the control of skeletal...
TheTP53gene is one of the most commonlymutated genesin cancers, and its encoded protein, p53, is aDNA damage responseregulator. Thereby, overcoming p53-induced cell-cycle arrest and cell death is one of the hallmarks of tumorigenesis. However,tumor suppressorp53 regulates autophagy with both negat...
p53 upregulates genes that encode cell cycle inhibitors, apoptosis inducers, DNA repair proteins, and metabolic regulators (Vousden and Prives, 2009). The p53 protein also downregulates genes associated with cell cycle progression, although the process involves CDKN1A/p21-dependent indirect mechanisms ...
The transcription factor TP53 is one of the most important tumour suppressors. TP53 prevents tumour development and progression by regulating target genes involved in cell cycle arrest, senescence, apoptosis, autophagy, metabolic reprogramming, tumour microenvironment signalling, and the suppression of cancer...
Metabolic reprogramming is a hallmark of cancer [90]. The mevalonate pathway, which regulates the production of cholesterol and isoprenoids, was reported to be involved in the development and progression of cancer [91]. Mutant TP53 expressing tumours often present with over-activation of the mevalon...
TP53 prevents tumour development and progression by regulating target genes involved in cell cycle arrest, senescence, apoptosis, autophagy, metabolic reprogramming, tumour microenvironment signalling, and the suppression of cancer cell migration and invasion.1,2,3,4,5,6,7 Given its central role in ...
CRC was classified into four subtypes with distinct molecular and biological characteristics: CMS1 (microsatellite instability immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal). Eight commonly used CRC cell lines were used in our experiment. According to previous reports, RKO ...
The terms related to biological processes were primarily associated with import into cells, cholesterol homeostasis, sterol homeostasis, the NMDA selective glutamate receptor signaling pathway, and primary alcohol metabolic processes. To summarize, these findings provided detailed insights into the potential ...
These GoF mutations render additional features to cancer cells such as enhanced invasiveness and metabolic reprogramming to facilitate tumor progression15,16,17. Unlike TP53 mutations which have been investigated for decades, only recent studies have provided in-depth characterization of hotspot mutations ...
The data clearly showed that both overexpression of miR-524-5p and TP53INP1 knockdown upregulated the expression of all four pluripotency genes tested in the transfected cells (Fig. 5f). Hence, the results support that miR-524-5p negatively regulates TP53INP1, which in turn regulates p53, to ...