I received even more devastating news. I learned that I had a mutation in a gene called TP53, or p53 for short. Known as the guardian of the genome, a mutation -- p53 is responsible for supervising the repair of our DNA. A mutation in this gene means errors...
What things can happen if you have a mutation? Is TP53 mutation genetic? What is genetic inheritance? What genetic conditions cause mutations in DNA structure? What causes acquired mutations? What is the germline BRCA mutation? What genetic mutation causes albinism? What genetic mutation causes neur...
Are most gene mutations hereditary or acquired? What type of genetic mutation is caused by 5-bromouracil treatment? What genetic conditions cause mutations in DNA structure? What is the most common autosomal recessive disease? What genetic mutations are associated with OCD? Is TP53 mutation genetic...
TP53is called the"Guardian of the Genome"due to its ability to protect cells from accumulating cancer causing mutations. TheTP53gene responds to DNA damage, or pre-cancer, by stopping the cell from dividing until the DNA can be repaired. If the cell cannot fix the DNA, thenTP53causes the ...
Li-Fraumeni syndrome (LFS) is a rare highly penetrant cancer syndrome characterized by mutation in the TP53 tumor suppressor gene. Recent data suggest that this germline mutation is more frequent than once thought. While LFS has not been associated previously with pelvic serous carcinoma, gynecologic...
Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas Aberrant activation of Ras signaling is a common finding in human glioblastomas. To determine the contribution of Ras gene mutations to this aberration, we... CB Knobbe,J Reifenberger,G Reifenberger - 《Acta...
The HER2 overexpression, gene amplification, or mutation have been described in breast, gastric, lung, and colorectal cancer. HER2 is a predictive biomarker for anti-HER2 target therapies and could be tested by IHC, FISH, and NGS. A systematic review and meta-analysis showed a HER2 expression ...
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The protein encoded by the TP53 gene responds to cellular stress and is implicated in regulating the expression of genes in different pathways, inducing cell cycle arrest, senescence, apoptosis, and DNA repair [123]. The lifetime risk for developing breast cancer in women who are TP53 mutation ...
Medullary carcinomas are typically high-grade lesions that are negative for ER, PR, and HER2 and that commonly demonstrate mutation of TP53. Mucinous carcinoma Mucinous (colloid) carcinoma is another rare histologic type, seen in fewer than 5% of invasive breast cancer cases. It usually presents ...