breast cancer / TP53 / mutations / carcinogensMutations in the tumour suppressor gene TP53 occur in about 30% of breast cancers. We have used the IARC TP53 mutation database to analyse the pattern of mutations in breast cancers (1392 mutations). The global pattern of mutations is similar to ...
Prognostic significance of p53 mutation in breast cancer: frequent detection of non-missense mutations by yeast functional assay Int J Cancer, 84 (1999), pp. 587-593 View in ScopusGoogle Scholar 26. C. Williams, T. Norberg, A. Ahmadian, et al. Assessment of sequence-based p53 gene analysis...
Invasive breast cancers in the highest quintile were significantly more likely to be interval breast Differences in somatic mutation profile Targeted gene exon sequencing of 39 known breast cancer driver and hereditary predisposition genes, including 28 DNA repair genes (Supplementary Table 3), was ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family h...
(1995). Detection of TP53 gene mutation in human meningiomas: a study using immunohisto- chemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin- embedded samples. Int. J. Cancer, 64, 223-228. TP53 mutation analyses in archival breast ...
BMC Cancer (2021) 21:186 https://doi.org/10.1186/s12885-021-07893-7 RESEARCH ARTICLE Open Access High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability Daniel R. ...
In addition, patients with missense mutations develop cancer at an earlier age compared with those carrying deletion mutations [9]. Thus, even from a clinical perspective, the loss of wild-type activity by a missense mutation in the TP53 gene is not equivalent to a haploinsufficiency state ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family history of LFS and very young age of onset. ...
forBCAR1gene along withTP53mutation status (wild type or mutant), survival months, and status (alive or dead). After filtering off samples with missing information, METABRIC dataset has 1904 samples composed ofTP53mutated (n = 659) andTP53wild type (n = 1245). TCGA PanCancer Atlas...
Furthermore, some co-existing gene mutations, such as TP53 mutation, can also affect the therapeutic effect and prognosis of patients. Whether EGFR mutation combined with TP53 mutation affects the sensitivity of lung cancer cells to tyrosine kinase inhibitor (TKI) and long-term prognosis of non-...