Germline TP53 mutations in breast cancer families with multiple primary cancers: is TP53 a modifier of BRCA1?Somatic mutations in TP53 are the most frequent events in human cancer and lead to inactivation of the gene, loss of tumour suppressor function, and in some cases generation of a ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family h...
Prognostic significance of p53 mutation in breast cancer: frequent detection of non-missense mutations by yeast functional assay Int J Cancer, 84 (1999), pp. 587-593 View in ScopusGoogle Scholar 26. C. Williams, T. Norberg, A. Ahmadian, et al. Assessment of sequence-based p53 gene analysis...
p53 protein, TP53 mutation, TP53 polymorphisms, breast cancer, prognostic factorTumor protein 53 (TP53) is a tumor suppressor gene that encodes tumor protein p53. Tumor protein p53 regulates the expression of target genes in response to cellular stress. Additionally, p53 participates in the ...
Influence of TP53 Gene Alterations and c-erbB-2 Expression on the Response to Treatment with Doxorubicin in Locally Advanced Breast Cancer TP53 status [mutations, immunostaining, and loss of heterozygosity (LOH)], expression of c-erbB-2, bcl-2, and histological grading were correlated to the r...
(1995). Detection of TP53 gene mutation in human meningiomas: a study using immunohisto- chemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin- embedded samples. Int. J. Cancer, 64, 223-228. TP53 mutation analyses in archival breast ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family history of LFS and very young age of onset. ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family history of LFS and very young age of onset. ...
[7] Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res. 2004; 64:7678–7681. [8] Sood AK, Armaiz-Pena GN, Halder J, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. ...
forBCAR1gene along withTP53mutation status (wild type or mutant), survival months, and status (alive or dead). After filtering off samples with missing information, METABRIC dataset has 1904 samples composed ofTP53mutated (n = 659) andTP53wild type (n = 1245). TCGA PanCancer Atlas...