DISEASE risk factorsSOMATIC mutationPULMONARY nodulesBackground: There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective lung cancer screening and better...
英文标题:TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk 发表期刊:2022年发表于《Hepatology》(IF =14.0) 应用技术:ChIP-seq、CRISPR、类器官 研究结论:利用ChIP-seq对TP53和H3K27ac联合分析,并通过CRISPR构建TP53缺失和TP53突变的肝脏类器官,揭示了TP53 缺失导致抑癌功能的丧失和...
西班牙巴塞罗那生物医学研究所(IRB)Fran Supek 教授课题组在国际知名期刊Nat Cancer在线发表题为“Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers”的论文。人类细胞中的突变在异染色质、晚期DNA复制时间(RT)染色体结构域中表现出增加的趋势...
3. Zenz, T., Kreuz, M., Fuge, M., Klapper, W., Horn, H., Staiger, A.M., Winter, D., Helfrich, H., Huellein, J., Hansmann, M.L., et al. (2017). TP53 mutation and survival in aggressive B cell ly...
5、Aggarwal C, Davis CW, Mick R, et al. Influence of TP53 Mutation on Survival in Patients With Advanced EGFR-Mutant Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2018, PO.18.00107. 6、Integrated analysis reveals ...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family h...
Tatsuya Masuda, et al., Impact of TP53 co-mutation on clinicopathological features, prognosis, recurrence patterns, and the efficacy of EGFR-TKI treatment after recurrence in resected early-stage EGFR-mutated lung adenocarcinoma, Clinical Lung Cancer (2025)....
^Sanchez-Lorenzo L, Sancho L, Iscar T, Grisham R, Chiva L. Management challenges in low-grade serous ovarian cancer with a BRCA mutation. Int J Gynecol Cancer. 2024 Apr 1;34(4):631-636. doi: 10.1136/ijgc-2023-005240. PMID: 38561200....
Tatsuya Masuda, et al., Impact of TP53 co-mutation on clinicopathological features, prognosis, recurrence patterns, and the efficacy of EGFR-TKI treatment after recurrence in resected early-stage EGFR-mutated lung adenocarcinoma, Clinical Lung Cancer (2025)....
development of risk-stratification, early detection and treatment strategies for TP53-mutant leukemia, and are of broad relevance to other cancer types. 编辑:胡肖希 美编:王乐 审核:辛嘉平 中国干细胞集团有限公司 www.chinacordblood...