We have performed a meta-analysis of cancer risk associated with the rs17878362 polymorphism of the TP53 suppressor gene (PIN3, (polymorphism in intron 3), 16 bp sequence insertion/duplication in intron 3), using a compilation of a total of 25 published studies with 10 786 cases and ...
et al. A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene 23, 1954–1956 (2004). Article CAS PubMed Google Scholar Strauss, B. S. Role in tumorigenesis of silent mutations in the TP53 gene. Mutat. Res. 457, 93–...
比较原发性的抗性和AR发现：1、患者的临床特征不同；2、AR患者的PD-L1初始表达水平更高；3、原发性抗性肝转移更常见；4、AR的总体生存率更高（图1C-E）。因此，AR具有与原发性抗性不同的临床特征和免疫分子学特点，值得进行进一步细致的分析。图1 2、AR to PD-1 blockade is associated with a distinct ...
spatial transcriptomics; Xenium In Situ; cancer evolution; cancer-associated fibroblast; extracellular matrix remodeling; SPP1+ macrophage; regulatory T cell; immune escape; NOTCH1 Introduction Para_01 理解致癌过程中复杂的机制对于探索肿瘤进化和识别早期干预的目标至关重要。 最近基因组学和单细胞转录组学的...
Association of TP53 codon 72 polymorphism with cervical cancer risk in Chinese women Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility t... P Jiang,J Liu,X Zeng,... - 《Cancer Gen...
(1989), which reported colorectal cancer cell lines containing one mutatedTP53allele and missing the other allele, an observation consistent with the theoretical hallmark of tumor suppressors (Knudson, 1985). The mutation/deletion ofTP53was soon demonstrated in many common tumor types (Nigroet al.,...
The expression of full-length TP53R273H, but not the BCAR1 binding-deficient mutant TP53R273HΔ102–207, promoted cancer cell invasion. Furthermore, among the patients with mutant TP53, high BCAR1 expression was associated with a poorer prognosis. Conclusions The interaction between TP53R273H and...
The unique role of TP53 in protecting against cancer is also illustrated by the fact that the Li-Fraumeni Syndrome (LFS), a familial syndrome of predisposition to multiple forms of cancer, is often associated with the germline transmission of a mutant TP53 allele 〚8〛. The p53 protein ...
在突变谱方面,PDAC主要突变涉及KRAS, TP53, CDKN2A和SMAD4等基因。但是,相较于肿瘤微环境的衍生信号,基因多样性对PDAC细胞的异质性贡献较低【4】。因此,PDAC的异质性主要受到局部组织信号的影响。为了弥补肿瘤内形态变异与PDAC异质性之间的...
Recently, TP53 is found to involve in regulating cell metabolic pathways besides its classical tumor suppressive functions. In addition, emerging evidence suggests that mutant TP53 is associated with cancer metastasis. Through summarizing and comparing the roles of wild-type TP53 and mutant TP53 in ...