HALL, A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects. Cell Death Dis., 4, e492 (2013).Sagne C , Marcel V , Amadou A , Hainaut P , Olivier M , Hall J . 2013a . A meta-analysis of cancer...
2 We have performed a meta-analysis of cancer risk associated with the rs17878362 polymorphism of the TP53 suppressor gene (PIN3, (polymorphism in intron 3), 16 bp sequence insertion/duplication in intron 3), using a compilation of a total of 25 published studies with 10 786 cases and 11...
PurposeThis study aimed to investigate the incidence of core domain TP53 mutations in Serbian breast cancer patients in view of their possible correlation with prognostic parameters, tumor characteristics and clinical disease course.Methods145 breast cancer patients were included. Data on clinical disease ...
TP53 was associated with colorectal cancer, but the different value levels of mRNA expression were not associated with survival rate of colon and rectal cancer. TP53 Pro allele and Pro/Pro genotype were associated with colorectal cancer risk in Asians. 展开 ...
KRAS、TP53和KGFR的突变以红色突出显示;b、与LUAD或LUSC相关的基因的PCA证实了样品的分类,基因列表取自Reili等人。c、用免疫相关基因组的表达水平计算TCGA的每个宏观区域及LUAD和LUSC肿瘤的炎症评分,如Danaher等人,将癌症患者的不同宏观区域(n=53个宏观区域)叠加在TCGA数据上(n=1011名TCGA患者)。d、每个宏观区域...
Recently, TP53 is found to involve in regulating cell metabolic pathways besides its classical tumor suppressive functions. In addition, emerging evidence suggests that mutant TP53 is associated with cancer metastasis. Through summarizing and comparing the roles of wild-type TP53 and mutant TP53 in ...
(1989), which reported colorectal cancer cell lines containing one mutatedTP53allele and missing the other allele, an observation consistent with the theoretical hallmark of tumor suppressors (Knudson, 1985). The mutation/deletion ofTP53was soon demonstrated in many common tumor types (Nigroet al.,...
Breast Cancer - TP53 PIN3 polymorphism associated with BACKGROUND: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a principal role in genomic stability, and its function va... Faghani,FM Ghasemi,M Nikhbakht,... 被引量: 0发表: 0年 加载更多来源...
Greenblatt MS, Chappuis PO, Bond JP, Hamel N, Foulkes WD: TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution. Cancer Res. 2001, 61: 4092-4097. CAS PubMed Google Scholar De Cremoux P, Salomon AV, Liva S, ...
No genotype was associated with a significantly better or worse progression-free or overall survival. CONCLUSION: The combined mutation status of KRAS and TP53 does not predict response to CAPOX in patients with metastasized colorectal cancer. 展开 ...