Promyelocytic Leukemia Zinc Finger-Retinoic Acid Receptor α (PLZF-RARα), an Oncogenic Transcriptional Repressor of Cyclin-dependent Kinase Inhibitor 1A (... Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα) is an oncogene transcriptional repressor that is generated by a chromo...
ATP53polymorphism is associated with increased risk of colorectal cancer and with reduced levels ofTP53mRNA. Oncogene. 2004;23:1954–6.Gemignani, F, Moreno, V, Landi, S, Moullan, N, Chabrier, A, Gutiérrez-Enríquez, S, Hall, J, Guino, E, Peinado, MA, Capella, G, Canzian, F (...
TP53 was the most commonly mutated gene consistent with prior genomic studies of TNBC. At 16.7 months of median follow-up, detection of ctDNA was significantly associated with an inferior DDFS (median DDFS 32.5 months vs. Not Reached, p=0.0030). At 24 months, the DDFS probability was 53% ...
The MDM2 gene is a cellular proto-oncogene, that is often amplified in ∼7% of all human cancers.26 Two promoters have been identified in MDM2 gene structure: a constitutive promoter and a TP53-response intronic promoter (P2).27, 28 From our previous study, the expression of MDM2 gene ca...
Next, we asked whether the drug combination shows superior anti-leukemic activity to the single agents, in two murine models of AML.Trib2is an oncogene capable of causing AML in mice through down-regulation of the transcription factor C/EBPα, a gene that is mutated in 15% of cases of AM...
TP53 mutation is an independent prognostic marker for poor outcome of radiotherapy in squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1998;42:43.Overgaard, J., Sorensen, S. B., Stausbol-Gron, B., Hoyer, M., and Alsner, J. TP53 mutation is an independent...
CHEK2 can paradoxically function as a potential oncogene in HCC, as our research findings suggest. In line with our study, Wu et al. have also reported similar conclusions [15]. This discrepancy may be attributed to the distinct tumor microenvironment in HCC compared to the other two types of...
This work demonstrates that not only exists a positive feedback loop between Atox1 and cyclin D1 but also that the activity of this loop depends on the status of the TP53 gene. Upon inactivation of TP53 in A549 and HepG2 cell lines, the expression of ATOX1 and CCND1 genes is enhanced...
Human colorectal tumors with wild-type TP53 and high PBF expression also had low p53 protein levels (P < 0.05), further emphasizing a putative interaction between these genes in vivo. Overall, these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53...
To provide a comprehensive view of the genomic alterations in GS, we generated an integrated genomic data set from whole-exome sequencing (WES) and a CNA analysis. Recurrent TP53 mutations were detected in 71% of the GS patients, and these patients showed a significantly shorter survival. In ...