Proto-oncogenes and tumor suppressor genes are primarily involved in orchestrating normal growth and differentiation – except for p53, which seems to be dedicated to controlling abnormal growth. Introduction Despite the way they were discovered, it is hard to believe that nature has furnished us wit...
F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor Background & Aims The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades several proto-oncogenes including c-Myc, cyclinE, Notch1,... R Sa...
The p53 protooncogene can act as a suppressor of transformation Cell, 57 (1989), pp. 1083-1093 View PDF View article View in Scopus Google Scholar Hinds, et al, 1989 Hinds P., Finlay C., Levine A.J. Mutation is required to activate the p53 gene for cooperation with the ras oncogene...
Oncogene Submit manuscript Daitoku Sakamuro, Peter Sabbatini, Eileen White & George C Prendergast 700 Accesses 250 Citations 3 Altmetric Explore all metrics Abstract p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region ...
p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. Oncogene. 2011; 30 :2670–8. doi: 10.1038/onc.2010.635. [ Cross Ref ]Testoni B,Schinzari V,Guerrieri F, et al.p53-paralog DNp73oncogene is repressedby IFN...
Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. Impact of miRNAs on eEF1A2 at the mRNA and protein l
Functional antagonism between c-Jun and MyoD proteins: a direct physical association. The product of the proto-oncogene Jun inhibits myogenesis. Constitutive expression of Jun in myoblasts interferes with the expression and the function of M... E Bengal,L Ransone,R Scharfmann,... - 《Cell》 被...
p53 has in differentiated cells, p53 controls transcription of pro-proliferative genes in embryonic stem cells includingc-mycandc-jun. The impeded anti-proliferative activity of p53 and the induction of certain proto-oncogenes by p53 in murine embryonic stem cells can explain why stem cells ...
p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region located between p53's transactivation and DNA binding domains is necessary to induce apoptosis but not cell growth arrest. The PP region was dispensable for DNA binding, ...
Proto-Oncogene Proteins c-bcl-2Restriction MappingTransfectionThe bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using p53-deficient tumor cell lines, wild-type but not mutant p53 expression plasmids transactivated a reporter gene ...