Proto-Oncogene Proteins c-bcl-2Protein IsoformsTransfectionApoptosisIt is now well accepted that the p53 C-terminus plays a central role in controlling the activity of the wild-type molecule. In our previous studies, we observed that a C-terminally altered p53 protein (p53AS), generated by an...
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life Mol. Cell. Biol., 8 (1988), pp. 531-539 View in ScopusGoogle Scholar Finlay, et al, 1989 Finlay C.A., Hinds P.W., Levine A.J. The p53 protooncogene can...
Proto-oncogenes and tumor suppressor genes are primarily involved in orchestrating normal growth and differentiation – except for p53, which seems to be dedicated to controlling abnormal growth. Introduction Despite the way they were discovered, it is hard to believe that nature has furnished us wit...
Proto-Oncogene Proteins c-bcl-2Restriction MappingTransfectionThe bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using p53-deficient tumor cell lines, wild-type but not mutant p53 expression plasmids transactivated a reporter gene ...
p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region located between p53's transactivation and DNA binding domains is necessary to induce apoptosis but not cell growth arrest. The PP r
Thus, we hypothesized that LOH is a second determinant of mutp53 stabilization and GOF in vivo. To test this, we combined the heterozygous hotspot GOF allele R248Q ('p53Q/+')5,10 with the MMTV-Neu ('Neu') oncogene19 expressing additional wild-type HER2 copies selectively in the mammary...
p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region located between p53's transactivation and DNA binding domains is necessary to induce apoptosis but not cell growth arrest. The PP region was dispensable for DNA binding, ...
(A) AURKA negatively regulates p53. AURKA phosphorylates p53 at S215, which inhibits its transcriptional activity. AURKA also inhibits p53-mediated gene expression by phosphorylating its co-activator hnRNPK at S379, which disrupts its interaction with p53. AURKA triggers MDM2-mediated p53 degradation...
At the molecular level, melanoma is characterized by activation of oncogenes and loss of tumor suppressor genes. To date, the identification of numerous genetic alterations in melanoma [2] has advanced our understanding of its etiology and pathogenesis. Analysis of the TCGA melanoma cohort described...
Vousden, K.H. and Prives, C. (2009). Blinded by the light: the growing complexity of p53. Cell137, 413–431.10.1016/j.cell.2009.04.037Search in Google ScholarPubMed Wassermann, K., Zwelling, L.A., Mullins, T.D., Silberman, L.E., Andersson, B...