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p53, phosphorylated (S33) (Cellular Tumor Antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor Suppressor p53, TP53, P53) Basic information More.. Product Name: p53, phosphorylated (S33) (Cellular Tumor Antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor Suppressor p53, TP53, P53)...
Conversely, p53 knockout and PAI-1 overexpression induce CS [123]. SASP factors such as IL-6 and CXCR2 maintain cell cycle arrest via p53, thereby inhibiting tumor cell growth and proliferation [124,125,126]. Although the precise mechanism by which SASP maintains cell cycle arrest is not ...
Results : Gene expression (RNA-seq) analysis of the NPM1 mut OCI-AML3 cell line demonstrated that CM-272 induces up-regulation of the TP53 gene signature. These transcriptional changes were confirmed by p21 induction, a downstream target of TP53 . Combining CM-272 with p53 antigen-TCR-...
Shelterin proteins (TERF1, TERF2, TPP1, TINF2, POT1) protect telomeres, prevent unwarranted repair activation, and regulate telomerase activity. Alterations in these proteins can lead to cancer progression. This study uses an in-silico approach to examin
antigen presentation and immune cell differentiation, thereby impairing the ability of the immune system to clear senescent or damaged cells, further perpetuating the cycle of inflammation and senescence [68]. Moreover, this chronic inflammatory environment can foster tumor growth by supporting cell ...
TP53: Tumor Protein P53 LKB1: Liver kinase B1 KRAS: Kirsten ratsarcoma viral oncogene homolog KO: Knockout ARID1A: AT-rich interaction domain 1A CDKN2A: Cyclin-dependent kinase inhibitor 2A TP53/CDKN2A(KO): TP53 and cyclin-dependent kinase inhibitor 2A (CDKN2A) knockout GEJ: Gastro...
B. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway. Science 350, 568–571 (2015). Article PubMed CAS Google Scholar Liu, H. S. et al. Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release. PLoS...
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal clinical benefit, and most GBM patients experience tumor recurrence after treatment. In recent years, significant advancements have be
The combined model added expression data from four genes: ITGB3, cellular tumor antigen p53 (TP53), laminin B1 chain (LAMBl), and tissue-type plasminogen activator (PLAT; protein name, t-PA). Gene expression profiles help identify metastasis MICROSCOPIC FEATURES: H and E section studied shows...