The occurrence of TP53 mutations is considerably influenced by cancer-initiating events, such as DNA damage, the aftermath of which is the promotion of cancer development through the loss of anti-proliferative activities, including apoptosis and cellular senescence. Over 27.000 TP53 gene mutations have...
Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. Mol Cell Biol 1998; 18:3692–3698. PubMed CAS Google Scholar Brachmann RK, Vidal M, Boeke JD. Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proc Natl Acad...
1985). The mutation/deletion ofTP53was soon demonstrated in many common tumor types (Nigroet al., 1989), and the cancerprone Li-Fraumeni Syndrome, which is characterized by a familial clustering of early (< 45 years) onset tumors, was found to be caused by germline mutations in theTP53gene...
Most mutations in TP53 in human cancers cause a single amino acid substitution, usually within the DNA binding domain of the TP53 protein. These mutant TP53 proteins are often expressed at high levels in the malignant cells. Three cancer causing attributes have been postulated for mutant TP53 ...
Mutations in TP53 block its tumour suppressive functions by preventing it from binding to target DNA sequences and upregulating genes that mediate several cellular processes, including apoptosis, cell cycle arrest and senescence. Mutant TP53 proteins are also reported to have gain-of-function properties...
2. La Fleur L, Falk-Sörqvist E, Smeds P, et al.Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11[J]. Lung Cancer,...
Mutations in the CHEK2 gene have been found to be correlate with various cancers, particularly hereditary cancers like breast and colorectal cancer [11, 12]. Specifically, mutations in the CHEK2 gene can result in the loss or impairment of protein function, affecting DNA repair and cell cycle ...
toledo和wahl,“调节p53路径:体外假设、体内真实情况(regulatingthep53pathway:invitrohypotheses,invivoveritas),”nat.rev.cancer,6(12):909,2006. vazquez等,“p53路径的遗传学、细胞凋亡和癌症治疗(thegeneticsofthep53pathway,apoptosisandcancertherapy),”nat.rev.drugdiscov.,7(12):979,2008. ...
The incidence of colorectal cancer and cancer death rate are increasing every year, and the affected population is becoming younger. Traditional Chinese medicine therapy has a unique effect in prolonging survival time and improving the prognosis of patie
Caused by mutations in the tumor suppressor gene TP53, individuals with the syndrome have a 90% risk of cancer by age 60 years. ACOG spells out risk assessment for hereditary cancer Background: Tumour suppressor genes such as TP53, BRCA1 and RAD51 are involved in DNA repair and their malfun...