A rare missense mutation in the tetramerization domain of exon 10 of the TP53 gene was found to segregate with malignant disease in this family. Lack of response to various chemotherapies and radiotherapy could be ascertained by histopathology of surgical specimens after neoadjuvant treatment, by ...
Influence of TP53 Gene Alterations and c-erbB-2 Expression on the Response to Treatment with Doxorubicin in Locally Advanced Breast Cancer TP53 status [mutations, immunostaining, and loss of heterozygosity (LOH)], expression of c-erbB-2, bcl-2, and histological grading were correlated to the r...
Treatment strategies of p53 dysfunction.aInhibition of the interaction between wild-type p53 and MDM2/MDM4: RG7112 and RG7338 are MDM2 inhibitors that hinder direct interaction between p53 and MDM2. ALRN-6924 is a dual MDM2/MDM4 inhibitor. RG7112, RG7338, and ALRN-6924 are currently undergoin...
[14] Hof J, Krentz S, van Schewick C, et al. Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. J Clin Oncol. 2011. 29(23): 3185-93. [...
A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma[J]. BMC Cancer, 2021, 21(1): 1035. [16] VENTON G, COURTIER F, CHARBONNIER A, et al. Imp...
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展开更多 Objective To investigate the efficacy of combination chemotherapy with sindilizumab and platinumcontaining double-drug in the treatment of TP53 gene mutated non-small cell lung cancer.Methods A total of 72 non-small cell lung cancer patients with TP53 gene mutation admi...MORE 作者 ...
There are different subtypes of TP53 gene mutations in lymphoma, each with its own implications for diseaseprogression and treatment outcomes. For example, the TP53 mutation known as "missense mutation" results in a change in a single amino acid in the p53 protein, affecting its structure and fu...
[关键词 ] 前列腺癌 ;TP53 基因 ;预后 ;基因检测 ;突变 DOI:10.13201/j.issn.1001-1420.2022.12.004 [中图分类号 ] R737.25 [文献标志码 ] A ClinicalfeaturesandprognosticvalueofTP53genemutation inpatientswithprostatecancer QIFeng LIXiao XU Weizhang CAI Hongzhou XU Ting YU Bin ZOU Qing XU Zicheng (...
Information about treatment status was incomplete or absent in over a third of the cohort, although no disease-modifying therapy, including stem cell transplantation, has been definitively shown to mitigate the adverse impact of TP53 mutation. Only 27 patients (8%) were reported as having received...