A rare missense mutation in the tetramerization domain of exon 10 of the TP53 gene was found to segregate with malignant disease in this family. Lack of response to various chemotherapies and radiotherapy could be ascertained by histopathology of surgical specimens after neoadjuvant treatment, by ...
Gene mutations can impair the sensitivity of cancer cells to targeted drugs, and lead to individual differences of clinical therapeutic effects. Epidermal growth factor receptor (EGFR) mutation plays an important role in therapeutic decision-making. Furthermore, some co-existing gene mutations, such as...
H460 LSL/Δ/Δ 细胞是由 NCI-H460 细胞通过相同的程序产生的,特别注意的是这个细胞系有三个 TP53 等位基因,这意味着它必须包含两个 Δ 等位基因和一个 LSL 等位基因。 Generation and treatment of mutant cells and cell libraries 突变细胞的生成和处理以及细胞库的建立 Para_01 为了生成单突变体,将2.5 ×...
[14] Hof J, Krentz S, van Schewick C, et al. Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. J Clin Oncol. 2011. 29(23): 3185-93. [...
DMS studies using cDNA overexpression are blind to mutation effects on RNA splicing, which can result in LOF through NMD. In our CRISPR-based screen, 55 of 56 previously reported splice-altering TP53 variants were enriched under N3a treatment, displaying positive RFS values indicative of LOF (Sup...
[关键词 ] 前列腺癌 ;TP53 基因 ;预后 ;基因检测 ;突变 DOI:10.13201/j.issn.1001-1420.2022.12.004 [中图分类号 ] R737.25 [文献标志码 ] A ClinicalfeaturesandprognosticvalueofTP53genemutation inpatientswithprostatecancer QIFeng LIXiao XU Weizhang CAI Hongzhou XU Ting YU Bin ZOU Qing XU Zicheng (...
Information about treatment status was incomplete or absent in over a third of the cohort, although no disease-modifying therapy, including stem cell transplantation, has been definitively shown to mitigate the adverse impact of TP53 mutation. Only 27 patients (8%) were reported as having received...
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A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma[J]. BMC Cancer, 2021, 21(1): 1035. [16] VENTON G, COURTIER F, CHARBONNIER A, et al. Imp...
展开更多 Objective To investigate the efficacy of combination chemotherapy with sindilizumab and platinumcontaining double-drug in the treatment of TP53 gene mutated non-small cell lung cancer.Methods A total of 72 non-small cell lung cancer patients with TP53 gene mutation admi...MORE 作者 ...