TP53 gene abnormality has been reported to be an unfavorable prognostic factor in acute myeloid leukemia (AML). However, almost all studies of TP53 gene abnormality so far have been limited to mutation searches in the DNA binding domain. As there have been few reports examining both mutation ...
Sixteen of the gene-level signals arose from the rare protein-truncating ‘PTV’ QV model. Six of these genes were associated with telomere shortening (ATM,BRIP1,NAF1,PARN,RTEL1andTERT), five of which have been implicated in known telomere-related clinical diseases, including IPF30,31,32, ...
When telomeres shorten beyond a certain length, double-strand break repair is activated and cell cycle progression is arrested via the TP53 pathway28. Failure to block cell growth can lead to telomere crisis and subsequent translocations, chromothripsis or chromosome fusions29. We explored the associat...
It is thought that KRAS (not BRAF) and TP53 gene mutations are linked to the CIN-associated carcinogenesis [31], [32], [33], [34]. A number of studies have reported that accelerated telomere shortening is observed in colorectal cancer lesions when compared to adjacent non-cancerous lesions...
TP53 genetic polymorphisms and susceptibility to cervical cancer in Bangladeshi women: a case-control study Pharmacogenetic study of TP53 gene polymorphisms has not been conducted extensively in cervical cancer. The aim of this study was to assesses the TP53 codo... MNH Apu,AZM Rashed,T Bashar,....
We examined the impact of the selective PPARγ agonist efatutazone on mammary cancer pathogenesis in a mouse model of BRCA1 mutation. Mice with conditional loss of full-length BRCA1 targeted to mammary epithelial cells in association with germline TP53 insufficiency were treated with efatutazone ...
p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell 2007; 27: 647–659. CAS PubMed Google Scholar Candi E, Agostini M, Melino G, Bernassola F . How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat ...
Eight mammalian species with accession number and length (bp) of coding sequences for TP53 gene.Tarikul, Huda MazumderSupriyo, Chakraborty
We examined the effect of TP53 gene expression on both telomere metabolism and chromosome stability in immortal, telomerase-positive cell lines. Telomere length, telomerase activity, and chromosome instability were measured in multiple clones isolated from three related human B-lymphoblast cell lines that...
f, TP53−/− cells and parental HCT116 cells were depleted of SGO2 and securin, taxol-arrested and analysed by immunoblotting. Source Data Extended Data Fig. 12 MCL1 cleavage by separase and the pro-apoptotic effect of MCL1-C is conserved in non-mammalian vertebrates. a, 35S-labelled...