The TP53 tumor suppressor gene is located on chromosome 17p13.1 and encodes a ubiquitous phosphoprotein of molecular mass 51,000–53,000, essentially expressed in the nucleus. This gene is frequently inactivated by somatic mutation or by loss of alleles in many common human cancers. More than 25...
TheTP53gene is located onchromosome 17. The Tp53 protein is a negative regulator ofcell proliferationand a positive regulator ofapoptosisinresponse to DNA damagingagents.TP53is the most common mutated gene associated with human cancer. Li-Fraumeni syndrome is a multicancer predisposition syndrome that...
The TP53/CCP17 FISH Probe Kit is designed to detect the human TP53 gene located on chromosome band 17p13.1, along with the number of chromosome 17 copies per cell.* Abnormal expression of the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 –has been observed in a large number...
The TP53 gene is located on chromosome 17 and is a tumor suppressor gene [18]. The mutation of TP53 can be reflected in most malignant tumors and can be seen in all types of lung cancer [19, 20]. Previous literature has shown that mutations in TP53 can activate abnormal cell proliferatio...
The frequency of chromosome 17p loss was increased in the low-MD compared to high-MD cancers, even after adjustment for tumor histology. This pattern of genomic alteration is consistent with the TP53 mutation data in low-MD cancers. TP53 is located on 17p13.1 and is considered to be the ...
The TP53/ATM FISH probe set is designed to detect copy number changes in the region of the human TP53 gene and ATM gene located on chromosome band 17p13.1 and 11q22,3, respectively. The kit contains two differentially labeled probes: A Locus Specific Probe (LSP), TP53, covers a chromosoma...
The TP53 gene, which encodes the p53 protein, is located on chromosome 17 (17p13.1), contains 11 exons, and its expression is controlled by two promoter regions giving rise to 12 different p53 protein isoforms [9]. This gene has numerous polymorphisms, and some of them are known to alter...
Background: Tumor protein 53 (TP53), located on the short arm of chromosome 17, is an important tumor suppressor gene responsible for critical regulatory functions. There is existing controversy regarding the role of allogeneic stem cell transplantation (allo-SCT) in patients with acute myeloid ...
Considering OS,TP53mutation and p53 expression are not associated withpatients’ outcome. Similarly,TP53mutationslocated in exons 5–8 have no prognostic value in the present series. Finallywhen considering both 1p/19q andTP53statuses, no...
The TP53/ATM/D13S319/LAMP1/CCP12 FISH Probe Kit is designed to simultaneously detect rearrangements involving the human TP53, ATM, D13S319 and LAMP1 genes, located on chromosome bands 17q13.1, 11q22.3, 13q14.2, and 13q34, respectively. Gains and losses of these loci have been observed ...