TheTP53gene is located on chromosome 17. The Tp53 protein is a negative regulator of cell proliferation and a positive regulator of apoptosis in response to DNA damaging agents.TP53is the most common mutated gene associated with human cancer. Li-Fraumeni syndrome is a multicancer predisposition syn...
Tumor protein p53 (TP53) located on chromosome 17p13 is frequently mutated in cancer, including myeloid neoplasms (MN). Approximately 7–11% ofde novomyelodysplastic syndromes (MDS) and 10–13% of acute myeloid leukemia (AML) patients harborTP53mutations (TP53mut) [1,2,3,4,5,6,7,8,9,1...
The TP53/MPO FISH Probe Kit is designed to detect rearrangements involving the human TP53 and MPO genes, located on chromosome bands 17p13.1 and 17q22, respectively. Abnormalities in both genes, the TP53 gene – also known as P53, BCC7, LFS1 or TRP53 –and the MPO gene, have been repo...
TheTP53tumor suppressor gene located at chromosome region 17p13.1 encodes the p53 protein, which is involved in the regulation of cell cycle, DNA repair, apoptosis, and senescence after various stress signals, such as DNA damage and inflammation4. Loss of p53 function allows proliferation of cells...
Tumor protein 53 (TP53) is the most frequently mutated gene in human cancer which located on the short arm of chromosome 17. In hematological malignancies, the prevalence of TP53 mutations is low compared to other tumors but associated with a complex karyotype, poor prognosis, and poor response...
The tumor suppressor gene TP53, located on chromosome 17p13, encodes the transcription factor p53, which carries out multiple antiprolif-erative functions in AML and many other cancer types.3 Mutations in TP53 are present in approx-imately 10% of patients with AML, who may also have other ...
Considering OS,TP53mutation and p53 expression are not associated withpatients’ outcome. Similarly,TP53mutationslocated in exons 5–8 have no prognostic value in the present series. Finallywhen considering both 1p/19q andTP53statuses, no...
The TP53/ATM/D13S319/LAMP1/CCP12 FISH Probe Kit is designed to simultaneously detect rearrangements involving the human TP53, ATM, D13S319 and LAMP1 genes, located on chromosome bands 17q13.1, 11q22.3, 13q14.2, and 13q34, respectively. Gains and losses of these loci have been observed ...
4) the R175H mutant is uniquely associated with CNV and allelic LOH on chromosome 9; 5) upstream pathways associated with specific TP53 mutants show distinct gene expression differences; 6) p53 activity (luciferase activity, target gene expression, and cell viability in response to nutlin-3a) in...
SNP rs7519753 is a genome-wide significant locus associated with HBsAg loss The rs7519753, located 18 kb upstream of tumor protein p53 binding protein 2 (TP53BP2)on chromosome 1q41, was found to be significantly associated with HBsAg loss after Peg-IFNα therapy (p= 4.86 × 10-8,Fig. 2A...