1), TP53wt samples had higher counts of the non-targeting sgRNAs. This suggests that p53 activity exacerbates DSB toxicity, such that a lack of DSB is particularly advantageous to TP53wt cells, in relative terms. Overall, our data suggests that DSB created by Cas9 in various genomic ...
Nuclear p53 Expression Is Associated With Allelic Imbalance (TP53) in Glandular Dysplasia and Typical Cystitis Glandularis: A LCM-Based Molecular Analysis[J] . Supriya Srivastava,Benedict Yan,Sze Yung Chin,Tuty Muliana,Manuel Salto-Tellez,Ming Teh.Clinical Genitourinary Cancer . 2012 (1)...
Furthermore, in vitro and in vivo experiments, the knockdown of circGLIS3 improved the response of PCa cells to ARSI therapies such as enzalutamide. Conclusions METTL3-mediated m6A modification of circGLIS3 regulates the p53 signaling pathway via the miR-661/MDM2 axis, thereby facilitating PCa ...
Functionally, we found that TP53 mutations are associated with the epithelial–mesenchymal transition (EMT) process of sarcomatous components of GS. We provide the first comprehensive genome-wide genetic alternation profiling of GS, which suggests novel prognostic subgroups in GS patients based on their...
Is the aberrant expression of p53 by immunocytochemistry a surrogate marker of TP53 mutation and/or deletion in chronic lymphocytic leukemia? Is the aberrant expression of p53 by immunocytochemistry a surrogate marker of TP53 mutation and/or deletion in chronic lymphocytic leukemia? Am J Clin ......
p53 itself. Moreover, mutations in RNF144B are largely mutually exclusive with mutations in p53 in several cancers, consistent with a notion that RNF144B and TP53 could function in the same pathway [23]. Importantly RNF144B role as a tumour suppressor in other cellular and oncogene driven ...
In this study, we evaluate the expression of p53 in core biopsies with acute myeloid leukemia and correlate the level of expression with acute myeloid leukemia subtype, TP53 mutation status, karyotype, and survival. Of the 143 cases evaluated, 71 fulfilled the WHO 2016 criteria for acute myeloid...
Given that the background level of expression of p53 in TP53 WT cases was very low in terms of the proportion of positive cells as well as intensity, we reasoned that an increased proportion of even dimly positive cells was significant. For this reason, we chose to count dimly positive ...
as challenging it turns out in practice. The most commonTP53mutations either destroy DNA contact residues or destabilize the thermodynamically labile p53 DNA binding domain and cause its denaturation at normal body temperature [27]. The most direct reactivation approaches aim to refold the pool of mu...
Rucker et al.9 showed that TP53 mutation was an independent poor risk factor for overall survival (OS) in AML patients with CK; however, the same finding could not be shown by Bowen et al.10 Whether there is geographic difference in the incidence of TP53 mutations in AML between Western ...