2]. Furthermore, germline heterozygous mutations inTP53cause the rare cancer predisposing Li-Fraumeni syndrome [3,4] and 100% of mice lackingTrp53develop tumours, primarily lymphomas or sarcomas highlighting the pivotal role of TP53 as a tumour suppressor [5,6,7]. TP53 operates as a transcrip...
Our study sheds light on the crucial role of the tumor suppressor gene TP53 in the regulation of global protein metabolism and in the adaptation to ER stress in the context of SMARCB1 loss. Our findings have profound implications regarding the current standard-of-care cytotoxic drug regimens ...
Thus, we asked whether sarcomas are more prone to p53 LOH than breast tumors. Indeed, qPCR of genomic DNA showed that p53 LOH occurs in all sarcomas, but rarely in breast cancer (Figure 3b). Moreover, the few breast tumors that did stabilize mutp53 also underwent p53 LOH. Together, ...
p53TP53The Cancer Genome Atlasmolecular classificationTP53 mutations are considered a surrogate biomarker of the serous‐like 'copy number high' molecular subtype of endometrial carcinoma (EC). In ovarian carcinoma, p53 immunohistochemistry (IHC) accurately reflects mutational status with almost 100% ...
1), TP53wt samples had higher counts of the non-targeting sgRNAs. This suggests that p53 activity exacerbates DSB toxicity, such that a lack of DSB is particularly advantageous to TP53wt cells, in relative terms. Overall, our data suggests that DSB created by Cas9 in various genomic ...
26 Two promoters have been identified in MDM2 gene structure: a constitutive promoter and a TP53-response intronic promoter (P2).27, 28 From our previous study, the expression of MDM2 gene can be indirectly enhanced in the EBV-infected NPC cells through enhancement of TP53 activation.29 Using ...
This finding is potentially even more significant, because TP53 mutations can be analyzed in urine cells by noninvasive methods (347,348). As newer 因此p53在病人也许起有用的分子生物标志作用对于确定预测和治疗战略有非侵入性的过渡细胞癌。 发现的这是潜在地更加重大的,因为TP53变化在尿细胞可以被分析由...
While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role of microRNA-876-3p (miR-87
We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss o
Rucker et al.9 showed that TP53 mutation was an independent poor risk factor for overall survival (OS) in AML patients with CK; however, the same finding could not be shown by Bowen et al.10 Whether there is geographic difference in the incidence of TP53 mutations in AML between Western ...