SASS6 was highly expressed in most tumors, reflecting a good diagnostic value, and its overexpression in LUAD indicated discouraging overall prognosis. Functional enrichment analysis suggested that SASS6 was associated with cell cycle in LUAD. In addition, patients with high SASS6 expression had ...
Pattern of TP53 mutations in human cancer: oncogenic hotspot mutant TP53 is one of the most frequently expressed protein variants in human cancer A unique feature of the TP53 gene compared with other tumor suppressor genes is its mode of inactivation.15, 16, 17, 18 More than 80% of somatic...
(C) The most significantly upregulated RNAs in mutant TP53 cancers are cell-division promoters. For each cancer, the top 100 and 500 gene RNAs most highly expressed in mutant, relative to wild-type, TP53 tumors were identified, and the top 20 upregulated genes across all mutant TP53 cancers...
The mutational landscape of TP53, a tumor suppressor mutated in about half of all cancers, includes over 2,000 known missense mutations. To fully leverage TP53 mutation status for personalized medicine, a thorough understanding of the functional diversity of these mutations is essential. We conducted...
However, there was little evidence that SNP-h2 estimates for HC are enriched for genes that are highly expressed in brain tissues or chromatin marks in neural and bone tissue/cell types, beyond chance (Supplementary Data 10) in the conducted HC meta-analyses. Combined genome-wide analysis of ...
Because NOLC1 was the most highly expressed gene among these three genes in NPC cells, it was chosen for further study. NOLC1 Gene Expression is Up-Regulated in Most NPC Tumor Cells To verify the differences in expression of the selected gene, we performed QRT-PCR analysis (Figure 1A) for...
is regulated by the phosphorylation ofTP53and its tumor suppressor role has been reported [24]. Tumors with a high expression ofAENare expected to be p53 functional, and indeed highly expressedAENwas associated withTP53WT status in our classifier’s coefficients. On the other extreme,COP1, a ...
This process is exemplified by inflammatory bowel disease (IBD), where prolonged gut inflammation has been shown to increase the risk of CRC by two- to six-fold [6–8]. Chronic inflammation- mediated CRC is known to be promoted by alterations in the microenvironment that support t...
Tissue microarray immuno- histochemistry confirmed active Src (pSrc) signalling, with Fyn being most abundantly expressed (76.1%). Conclusion: These results strongly indicate Src family kinases, in particular Fyn, as a potential target for the treatment of inoperable and metastatic chondrosarcomas, and...
integratingTP53mutations into clinical decision-making is limited by the complexity of their mutational landscape. MostTP53mutations are missense, with over 2,000 identified, predominantly clustering in the DNA-binding domain (DBD)2. While the ten most common (and also most studied) ‘hotspot’ muta...