3, 4 However, TP53 is also the most frequently mutated gene in human cancer, leading to nonefficient removal of tumor cells and to carcinogenesis.5 In gastric cancer, the TP53 gene is frequently mutated and p53 overexpression is observed in ∼50% of tumors.6 TP53 gene mutation results in...
Circulating tumor cells (CTCs) are tumor cells shed from either primary tumors or its metastases that circulate in the peripheral blood of patients with metastatic cancers. The molecular characterization of the CTCs is critical to identifying the key dri
The clinical importance of these potentially confounding factors is most easily established in context of large clinical trials with long follow-up and where data on numerous biomarkers are available. One such study is the phase III UK LRF CLL4 trial (NCT 58585610) that randomly assigned 777 ...
However, there was little evidence that SNP-h2 estimates for HC are enriched for genes that are highly expressed in brain tissues or chromatin marks in neural and bone tissue/cell types, beyond chance (Supplementary Data 10) in the conducted HC meta-analyses. Combined genome-wide analysis of ...
Because NOLC1 was the most highly expressed gene among these three genes in NPC cells, it was chosen for further study. NOLC1 Gene Expression is Up-Regulated in Most NPC Tumor Cells To verify the differences in expression of the selected gene, we performed QRT-PCR analysis (Figure 1A) for...
The machine learning method divided patients with TNBC into two groups characterized by 'hot' and 'cold' tumors, according to whether immune-associated genes were highly expressed, and different responses to immunotherapy were seen between these two groups. Furthermore, patients with a TP53MutPIK3CA...
in 13,622 probes carried forward in common for all subsequent analyses. An unpaired T test was applied for each comparison with p values calculated asymptotically and corrected for multiple comparisons using the method of Benjamini-Hochberg [14]. Fold changes for the probes are expressed relative ...
The lineage and architectural context within which DNA damage phenotype and oncogenic protein are expressed is relevant to current therapeutic developments that leverage macrophage phagocytosis to remove leukemic cells in part due to irreparable DNA damage. © 2024 The Pathological Society of Great ...
increasedGATA1expression in Lin-CD34+TP53multihit HSPCs, whereasCEBPAwas only expressed at low levels (Fig.2g). Analysis of the BeatAML cohort revealed increasedGATA1and reducedCEBPAexpression in association withTP53mutation (Extended Data Fig.5l), with consequent reduction in theCEBPA/GATA1expression ...
Telomerase is expressed in almost all organs of mice, while absent or not detectable in most organs of humans. In addition, only p53 function is required for the replicative arrest of murine cells but inactivation of both the p53 and p16 pathways are needed for human cells to become malignant...