The p53 protein is a transcription factor involved in processes of cell growth and differentiation. The muscle creatine kinase (MCK) gene whose transcription is induced during muscle differentiation contains p53
The p53 protein is a transcription factor that functions as a suppressor of tumor formation. The TP53 gene is the most commonly mutated gene in a wide variety of human cancers and the functions of the wild-type p53 protein are frequently compromised in many types of cancers.1The mutations loc...
During hypoxia in human cancer cells several proteins that favor cell survival are produced, including p53 (Graeber et al., 1994, Lee et al., 2012). The p53 protein is a phosphonuclear transcription factor that is activated in response to different types of stress including DNA damage, tumor...
The p53 protein, encoded by the Trp53 gene, is a transcription factor that responds to cellular stress to alter the transcription of genes that regulate an array of biological processes including necroptosis (Wang et al., 2016), apoptosis, cell- cycle arrest, and proliferation (Miller et al....
The p53 protein integrates cellular stress signals and functions as a transcription factor with many target genes whose transcripts are involved in DNA repair, cell cycle arrest, and activation of the apoptotic programme. So central is p53 to the life and death decisions of every cell that its ...
The Trp53 gene is the most frequently mutated gene in all human cancers. Its protein product p53 is a very powerful transcription factor that can activate different biochemical pathways and affect the regulation of metabolism, senescence, DNA damage resp
The tumour suppressor protein p53 is a transcription factor that induces proliferation arrest and cell death via nuclear and cytoplasmic activities.1,2Under conditions with an increased risk of mutagenesis, p53 levels rise and the tumour suppressor protein becomes post-translationally modified, resulting ...
The p53 tumor suppressor protein is a transcription factor with sequence-specific DNA binding activity that is thought to be important for the growth-inhibitory function of p53. DNA binding appears to require activation of a cryptic form of p53 by allosteric mechanisms involving a negative regulatory...
S. Fields et al, "Presence of a Potent Transcription Activating Sequence in the p53 Protein", Science, 249:1046-1049 (Aug. 31, 1990). J. Bargonetti et al, "Site-Specific Binding of Wild-Type p53 to Cellular DNA is Inhibited by SV40 T Antigen and Mutant p53", Genes & Development,...
2.The method of claim 1, wherein said p53 protein is wild type p53 of SEQ ID NO: 1, wherein said p53 protein is effective to promote vascular repair. 3.The method of claim 1, wherein said biodegradable polymer comprises a poly(lactide-co-glycolide), poly(lactic acid), poly(alkylene ...