Gene FrequencyGenesp53GeneticsPopulationHaplotypesHead and Neck Neoplasms基因频率基因P53It has been proposed that a constellation of three TP53 polymorphisms (intron 3 16 bp duplication, codon 72 BstUI, and intron 6 Nci I RFLP at nt 13494) constitute a haplotype predictive of increased cancer risk....
5d). In sample P2-TN1, the only predicted driver point mutation was a deleterious mutation in the tumour suppressor gene TP53, and this was detected in both DCIS and invasive compartments and was also present in all cancer regions of the second PBC, P2-TN2, consistent with an early onset...
infections, but no evidence for integration. HPV-positive and HPV-negative vulvar cancers exhibited contrasting human, global gene expression patterns partially overlapping with previously observed differences between HPV-positive and HPV-negative cervical and oropharyngeal cancers. A substantial fraction of t...
protein: Protein/Gene name to search AlphaFold structures, e.g., https://www.ncbi.nlm.nih.gov/Structure/icn3d/?protein=TP53&showanno=1&showsets=1 mmdbid: NCBI MMDB ID, e.g., https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=1tup&showanno=1&show2d=1&showsets=1 bcifid or...
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes Yutaro Hori Christoph Engel Takehiko Kobayashi Nature Reviews Molecular Cell Biology(2023) Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases ...
It is of high interest that cohesin mutations are often mutually exclusive with TP53 mutations in AML. This bears similarity to the mutually exclusive relationship between mutations in mammalian SWI/SNF and PTEN or TP53 mutations in human cancers [82]. This mutual exclusivity, or lack of cooccur...
structures makes it a potential ADAR substrate, and A-to-I editing can influence the stability and function of lncRNA by altering the structure of lncRNA and its interaction with miRNA [53]. This suggests a connection between RNA editing and gene silencing in terms of impeding gene regulation...
Through detailed characterization of its morphology, observable traits, and genome, LC53 was found to be virulent and comparable to other Serratia, Erwinia, and Kosakonia phages that fall under the Winklervirus genus. Genetic instability By screening a transposon mutant library, the host ompW gene ...
Although it has been known for a long time that some genomic alterations, such as mutations in the tumour suppressor genes TP53 and APC or the generation of fusion genes such as BCR-ABL are associated with specific tumors, often no known single driver mutation can be reliably identified. In ...
TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6-bisphosphatase (PFKFB) bisphosphatase domain. TIGAR is mainly located in the cy