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[1] p53 mutations in 10,000 cancer patients shed new light on gene's function [2] Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
抑癌基因TP53是人类肿瘤中最常发生突变的基因,一直是肿瘤学研究的重点和热点。肿瘤的发生发展与TP53突变引起的功能障碍密切相关。p53蛋白主要作为转录因子,调节多种细胞途径,如细胞周期阻滞、DNA修复、细胞凋亡和自噬等,并决定细胞在压力条件下是否死亡。多年来,一系列研究揭示了p53通路的复杂性,并延伸出其在代谢稳态、...
End 参考资料: [1] p53mutations in 10,000 cancer patients shed new light on gene's function [2] IntegratedAnalysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
参考资料: [1] p53 mutations in 10,000 cancer patients shed new light on gene's function
p53 is an obvious target for cancer therapy, despite the apparent intractability of a loss-of-function genotype. Two approaches are being taken to overcome this limitation—small molecules to restorep53 function74or inhibit its interaction withMDM2,75or adenoviral-mediated gene delivery. Although the...
参考资料: [1] p53 mutations in 10,000 cancer patients shed new light on gene's function [2] Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
Using a combination of in silico, functional, structural, and genetic approaches, we showed that none of these variants displayed loss of function compared to the normal TP53 gene. In addition, classification using ACMG criteria suggested that they are all benign. Considered together, our data ...