There are conflicting reports concerning the status and role of TP53 in MLS/RCLS. Here we analysed four MLS/RCLS derived cell lines for TP53 mutations, expression and function. Three SV40 transformed cell lines expressed normal TP53 proteins. Irradiation caused normal posttranslational modifications of...
Aging normal human oesophagus accumulatesTP53mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelicTP53disruption is almost universal. However, howp53mutant clones expand and contribute to cancer development is unclear. Here we show that inducing thep53R245Wmutant...
As a consequence of this mutation, the expression of the TP53 downstream gene CDKN1A (p21/WAF1/Cip1) is blocked. Based on experiments using TP53 antisense oligonucleotides, the radioprotective effect of BBI could be correlated with the function of wild-type TP53. Thus BBI can be considered as...
p53 is a major tumor suppressor as highlighted by the high prevalence of somatic mutations in TP53 in many cancer types, and the strong predisposition to multiple early-onset cancers in Li-Fraumeni (LFS) patients that carry germline mutations of TP53. Approximately 50% of human tumors harbor TP5...
In hematopoiesis, recent studies have indicated the essential and pleiotropic roles of O-GlcNAcylation in differentiation, proliferation, and function of hematopoietic cells including T cells, B cells, myeloid progenitors, and hematopoietic stem and progenitor cells. Moreover, aberrant O-GlcNAcylation is ...
(Fig.1eand Supplementary Fig.4d). It is conceivable that the elevated rate of SBS1 (a mutational signature predominantly characterized by C > T mutations at CG dinucleotides) was due to defective processing of G:T mismatches (a known function of the MMR system), and SBS44 is a ...
proteins are frequently upregulated, offsetting the function of proapoptotic proteins. therefore, ratio between apoptotic promoters and repressors in the bcl-2 family determines the chemosensitivity of cells to apoptotic stimuli. finally, determining the relationship between the p53 and main apoptotic ...
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling J Clin Invest, 117 (2007), pp. 2197-2204, 10.1172/JCI32205 View in ScopusGoogle Scholar [6] E. Elinav, R. Nowarski, C.A. Thaiss, B. Hu, C. Jin, R.A. Flavell...
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2. Bypass of senescence and crisis to become a cancer initiating cell 3. Telomerase in stem cells 4. Background review of cancer stem cells 5. Review of telomerase in cancer stem cells 6. Evidence for short telomeres in cancer stem cells 7. Self-renewal in cancer stem cells versus bulk ...