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the biological influences of many types of PTMs have been identified and are routinely analyzed in many systems. The importance of PTMs is known historically because of their effects on the enzymatic activity of kinases1and protein degradation2. Based on previous and emerging...
Cells that sustain mTOR activity (such as through the deletion of TSC2) progress to irreversible senescence, a process named geroconversion, whereas cells in which mTOR is inhibited (for example, through p53 activation or under hypoxia) ultimately achieve a reversible quiescent state (Korotchkina ...
The ability of wtp53 to induce cell migration could be co-opted by cancer cells, lending one possible advantage of its retention.;While p53 is found to enhance migration through the induction of Slug, p53 is also found to repress many other pro-migratory factors. EpCAM, a molecule highly ...
A functionally significant SNP in TP53 and breast cancer risk in African-American women. NPJ Breast Cancer. 2017;3:5. Wang Y, Yang L, Zhang X, Cui W, Liu Y, Sun QR, et al. Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53. EMBO Rep. 2019;20:e47563. PubMed Pub...
(fig.1). gsdmd regulates cgas-sting the pore forming activity of gsdmd is located in gasdermin-n domain, while the gasdermin-c domain inhibits its pore forming activity. the release of gasdermin-n domain migrated to the cell membrane, formed pores with an inner diameter of 10–15 nm, ...
Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the ...
Expression and activity of p53 protein is responsive to hormonal stimuli and varies across different stages of mammary gland development. Therefore, a major focus of the laboratory is to discover the normal cellular mechanisms that regulate p53 expression and function and determine whether sustained ...
TP53 and TP63 in BC cells and that, in the presence of mutant TP53, it interferes with its activity on target genes, resulting in inhibition of epithelial-to-mesenchymal transition and cell invasiveness [35]. A full list of these binding sites is available, with relevant information, in ...
The role of conformation in regulation of p53 stability and function In addition to the regulation of p53 protein levels, it is apparent that the p53 protein can adopt latent or active forms, most clearly seen as differences in sequence-specific DNA-binding activity. The extreme C-terminal regio...