它表明在患者中靶向NR4A和TOX因子的类似干预措施可能将基于CAR-T的免疫疗法的应用扩展到实体瘤中。相关研究结果于2019年5月31日在线发表在PNAS期刊上,论文标题为“TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion”。 图片来自PNAS, 2019, doi:10.10...
细胞毒性T细胞是对病毒感染和恶性肿瘤产生保护性免疫反应的必需调节物,并且是免疫治疗方法的关键靶标。然而,长期暴露于同源抗原通常会削弱T细胞的效应能力并限制它们的治疗潜力。这个称为T细胞衰竭(T-cell exhaustion)或功能障碍(T-cell dysfunction)的过程通过表观遗传强化的基因调控变化表现出来,这些变化降低细胞因子和效...
The transcription factor TOX epigenetically reprograms CD8+ T cells to drive T cell exhaustion during chronic infection and cancer. Although they are necessary for T cell persistence, these changes contribute to diminished anti-tumor function in exhauste
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'.Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9 3. Jean-Christophe, Beltra., Sasikanth, Manne., Mohamed S...
Nuclear factors TOX and TOX2 upregulate TIM3 expression and lead to T-cell exhaustion in malignancies. Here, we demonstrate two distinct TIM3 expression patterns (high & low) with high TOX and TOX2 levels in T-cell acute lymphoblastic leukemia (T-ALL) specimens and cell lines. However, the...
在题为“TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion”的研究中[2],Omar Khan等发现,TOX在不同的免疫细胞类型中含量不同,控制着耗竭T细胞的特性。 具体来说,研究揭示了TOX是耗竭CD8+T细胞的中心调控因子。TOX对...
在题为“TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion”的研究中[2],Omar Khan等发现,TOX在不同的免疫细胞类型中含量不同,控制着耗竭T细胞的特性。 具体来说,研究揭示了TOX是耗竭CD8+T细胞的中心调控因子。TOX对形成效应CD8+T细胞和记忆CD8+T细胞很大程度上可有可无,但对耗竭CD8+T细胞...
CD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol, 20(8), 0. doi:10.1038/s41577-020-0274-9 2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kalli...
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'. Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'. Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9