1 in various types of human cancer, which correlateswith tumor progression, metastasis, angiogenesis and poor prognostic outcome. For these reasons, different strategies to block TGF-! pathway in cancer have been developed and they can be classified in: (1) blocking antibodies and ligand traps; ...
TGF-beta signaling in cancer--a double-edged sword. Transforming growth factor (TGF) β1 is a potent growth inhibitor, with tumor-suppressing activity. Cancers are often refractile to this growth inhibition ... RJ Akhurst,R Derynck - 《Trends in Cell Biology》 被引量: 1473发表: 2001年 ...
The autocrine and paracrine effects of TGF-beta on tumor cells and the tumor micro-environment exert both positive and negative influences on cancer development. Accordingly, the TGF-beta signaling pathway has been considered as both a tumor suppressor pathway and a promoter of tumor progression and...
- 《Cancer Research》 被引量: 226发表: 2007年 MT1-MMP Activation of TGF-β Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer However,MT1-MMP expression in the cancer stroma can drive invasion of carcinoma cells in vivo, suggesting MT1-MMP may ...
Mechanisms of resistance to TGF-beta caused by modulation of cell cycle regulators and/or inactivation of components of the TGF-beta signaling transduction pathway such as C-myc and Smad4 have been demonstrated in human pancreatic cancer and squamous cell carcinoma cell lines. But, this has not ...
TGF-β signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: Role of the β-spectrin, ELF Katuri V, et al.TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF... SK ...
and inhibit angiogenesis. These effects maintain homeostasis in normal tissues and prevent the early stages of tumor formation. As a result of mutations or epigenetic modifications that are introduced during cancer progression, cancer cells can become resistant to the suppressive effects of TGF-beta si...
Deregulation of TGF-beta/BMP activity almost invariably leads to developmental defects and/or diseases, including cancer. The proper functioning of the TGF-beta/BMP pathway depends on its constitutive and extensive communication with other signaling pathways, leading to synergistic or antagonistic effects...
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. Leveraging The Cancer Genome Atlas (TCGA) multidimensional data in glioblastoma, we inferred the putative regulatory network between microRNA and mRNA usin... G Genovese,A Ergun,SA Shuk...
Inhibition of the TGF-beta signaling pathway in tumor cells. Transforming growth factor—β (TGF—β) plays an important physiologic role in the regulation of cell proliferation, motility, and apoptosis as well as e... K Podar,N Raje,KC Anderson - 《Recent Results Cancer Res》 被引量: 13...