【Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer】 TGFB在癌症中有双重作用,在正常细胞及癌症发生早期,TGFB具有抑癌作用,而在癌症发生后期,癌症细胞对TGFB的抗癌作用产生耐受,TGFB转变为促癌分子。 TGFB/SMAD作用过程:与细胞膜表面的TGFBR结合,随后激活SMAD。
【Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer】 TGFB在癌症中有双重作用,在正常细胞及癌症发生早期,TGFB具有抑癌作用,而在癌症发生后期,癌症细胞对TGFB的抗癌作用产生耐受,TGFB转变为促癌分子。 TGFB/SMAD作用过程:与细胞膜表面的TGFBR结合,随后激活SMAD。 TGF...
关键词:摇 胃癌;摇 TGFBR1;摇 基因突变 中图分类号:R735郾2摇 摇摇 文献标识码:A StudyofMutationsofTGFBR1GeneinGastricCancer ZENGKongxin,SHIWei,HUGuangsheng (DepartmentofDigestion,theFirstAffiliatedHospital,UniversityofSouthChina, Hengyang,Hunan421001,China) Abstract:摇 Objective摇 Torevealthemutationsof...
with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene...
Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. In normal tissue and the earl...
This finding has implications for a wider spectrum of disorders, including cancer, fibrosis and inflammatory and cardiovascular diseases, which are influenced by TGFβ.doi:10.1038/ng0804-790Rosemary J AkhurstPubMedNature GeneticsAkhurst RJ. TGF beta signaling in health and disease. Nat Genet. 2004...
原文出处:Kwon W, Choi SK, Kim D, et al. ZNF507 affects TGF-β signaling viaTGFBR1 and MAP3K8 activation in the progression of prostate cancer to anaggressive state.J Exp Clin Cancer Res. 2021;40(1):291. Publis...
TGF-beta signaling in cancer–a double-edged sword. Trends Cell Biol. 11, S44–S51 (2001). 46. Thrower, J. S., Hoffman, L., Rechsteiner, M. & Pickart, C. M. Recognition of the polyubiquitin proteolytic signal. Embo J. 19, 94–102 (2000). 47. Igarashi, A., Okochi, H., ...
Abstract 2832: Genetic variation in TGFB1, TGFBR1, TGFBR2, and prostate cancer risk and recurrence Background: The transforming growth factor-尾 (TGF-尾) signaling pathway has been reported to play a dual role in prostate carcinogenesis. Initially, TGF-尾 signaling inhibits tumor growth by its...
英文名称ARTS/SEPT4 中文名称 凋亡相关蛋白TGFb信号抗体 别名Apoptosis Related Protein TGFb Signalling; Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; bradeion; Bradeion beta; Brain