This is also the first population-based observational study to evaluate crosstalk between TGF-beta and ERalpha signaling pathways. The biological significance of these genes in breast cancer etiology is strongly supported and the results warrant confirmation in future studies....
TGF-β activates cPLA2α-mediated PGE2/EP1 and PPAR-γ/SMAD signaling pathways in human liver cancer cells: A novel mechanism for subversion of TGF-β-indu... Purpose: This paper analyzes the factors that influence secondary school students' choice of higher education options in Spain today and...
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer Zhen Zeng Minyang Fu Min Luo Molecular Cancer(2023) Advertisement Nature Communications (Nat Commun)ISSN2041-1723(online) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer resea...
Both pathways are imp... AG Green - 《Memorial University of Newfoundland》 被引量: 0发表: 2003年 The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer and survival, is helping to define the fragile areas where malignancies are likely to develop and shows promise ...
TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways PTEN acts as a tumor suppressor primarily by antagonizing the PI3K/AKT signaling pathway.PTENis frequently mutated in human cancers; however, in type II ...
Thus, there is a critical need to identify new targets and develop novel strategies to improve cancer immunotherapy. One promising approach is to target tumor-promoting pathways that suppress the immune response, such as the TGF-β pathway. TGF-β is a pleiotropic cytokine that is widely ...
FULL PAPER British Journal of Cancer (2014) 110, 724–732 | doi: 10.1038/bjc.2013.768 Keywords: CAFs; TGF-b; EMT; breast cancer Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-b signalling Y Yu1, C-H Xiao2,3, L-D Tan1,...
Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment 篇首: Breast cancers frequently metastasize to bone, a site of hypoxia and high concentrations of active TGFβ. Skeletal metastases involve interactions be... LK ...
Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways 2018, Oncogenesis TGF-β3 inhibits antibody production by human B cells 2017, PLoS ONE Histone demethylase RBP2 promotes malignant progression of gastric...
TGFbeta in Cancer. Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review J Massagué - 《Cell》 被引量: 1.0万发表: 2008年 Mechanisms of TGF-beta signaling from cell membrane to the ...