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1 in various types of human cancer, which correlateswith tumor progression, metastasis, angiogenesis and poor prognostic outcome. For these reasons, different strategies to block TGF-! pathway in cancer have been developed and they can be classified in: (1) blocking antibodies and ligand traps; ...
1 in various types of human cancer, which correlates with tumor progression, metastasis, angiogenesis and poor prognostic outcome. For these reasons, different strategies to block TGF-! pathway in cancer have been developed and they can be classified in: (1) blocking antibodies and ligand traps;...
TGF-beta inhibition in gliomas may curtail the production of autocrine survival factors, such as PDGF. Blocking TGF-beta in ER − breast cancer, on the other hand, might prevent primary or metastatic tumors from seeding and reseeding metastasis. Finally, in osteolytic bone metastasis, blocking...
TGFbeta in Cancer. The transforming growth factor beta (TGFbeta) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development... J Massagué - 《Cell》 被引量: 3916发表: 2008年 TGF beta: the molecular Jekyll and Hyde of cancer Transforming gr...
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TGF-β regulates both the tumor-forming and migratory abilities of various types of cancer cells. However, it is unclear how the loss of TGF-β signaling components affects these abilities in clear-cell renal cell carcinoma (ccRCC). In this study, we investigated the role of TGFBR3 (TGF-β...
TGF-beta 1 belongs to a family of pluripotent growth factors (TGF beta s) and has been implicated in the development and progression of human breast cancer. There are conflicting data though, suggesting that TGF-beta has the pontency both to promote and inhibit the progression of mammary neopl...
The role for transforming growth factor-beta (TGF-beta) in human cancer. Uncontrolled cellular proliferation is a hallmark of cancer. Thus, a relevant and important question is how cancer cells have escaped from normal growth re... L Gold - 《Crit Rev Oncog》 被引量: 822发表: 1999年 Genet...