11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000; 342(2):69-77.13. Papageorgis P, Stylianopoulos T. Role of ...
TGF-beta inhibition in gliomas may curtail the production of autocrine survival factors, such as PDGF. Blocking TGF-beta in ER − breast cancer, on the other hand, might prevent primary or metastatic tumors from seeding and reseeding metastasis. Finally, in osteolytic bone metastasis, blocking...
Molecular biology Regulation of ld1 by TGF-beta in breast cancer WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY Robert Benezra PavlovicSvetlanaBreast cancer remains one of the most common types of cancer in women in the developed world. Id proteins are highly expressed in triple-negative breast ...
TGF-beta signaling in cancer--a double-edged sword. Transforming growth factor (TGF) β1 is a potent growth inhibitor, with tumor-suppressing activity. Cancers are often refractile to this growth inhibition ... RJ Akhurst,R Derynck - 《Trends in Cell Biology》 被引量: 1483发表: 2001年 ...
remodeling. Generally, signaling is initiated with the phosphorylation of the cytoplasmic Smad signaling molecules, which results in their translocation to the nucleus where they modulate transcription. TGF-βs are often overexpressed in many disease states such as fibrosis, inflammation, and cancer. ...
Detection of TGF-beta RI/ALK-5 in LPS/Monensin-Stimulated Human Peripheral Blood Mononuclear Cells. TGF-beta RI/ALK-5 was detected in immersion-fixed human peripheral blood mononuclear cells (PBMCs) following stimulation with LPS and monensin using aGoat Anti-Human TGF-beta RI/ALK-5 Antigen Af...
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cancer activity and can be used to study ossifying fibrous dysplasia (FOP) and cancer. ...
Association between endogenous gene expression and growth regulation induced by TGF-β1 in human gastric cancer cells
[1]. Mahmoudi Rad M, et al. Expression of TGF-β3 in isolated fibroblasts from foreskin. Rep Biochem Mol Biol. 2015 Apr;3(2):76-81. [2]. Laverty HG, et al. TGF-beta3 and cancer: a review. Cytokine Growth Factor Rev. 2009 Aug;20(4):305-17. ...
benef i ts 7,8 . Here, following the fi nding that transforming growth factor-β (TGF-β) suppresses T helper 2 (T H 2)-cell-mediated cancer immunity 9 , we show that blocking TGF-β signalling in CD4 + T cells remodels the tumour microenvironment and restrains cancer progression. ...