In conclusion, therapeutic manipulation of the TGF-beta pathway opens great opportunities in future cancer therapy.JasminSectionsOttenSectionsCarstenSectionsBokemeyerSectionsWalterSectionsFiedlerSectionsEBSCO_As
cancer.TGFbetasuperfamilyligandssignalthroughcell-surfaceserine/threonine kinasereceptorstotheintracellularSmadproteins,whichinturnaccumulateinthe nucleustoregulategeneexpression.Inadditiontothisuniversalcascade,Smad- independentpathwaysarealsoemployedinacell-specificmannertotransduce ...
or modified antisense molecules, designed to target the desired cells (antisense linked to peptides or antibodies that specifically bind receptors or antigens expressed on the target cell surface) can be administered systemically. Alternatively, RNA molecules may be generated by in vitro and in vivo...
Ligand access to the signaling receptors is regulated by numerous secreted agonists and antagonists and by membrane-associated coreceptors that act in a context-dependent manner. Given the fundamental role of the TGFbeta superfamily in metazoans and the diversity of biological responses, it is not ...