Smad4 deficiency also enhanced the rate of aerobic glycolysis, a common feature of cancer progression, as well as enabled the increased survival of colon cancer cells growing under hypoxic conditions. In summary, these results demonstrated a wide array of TGFbeta/Smad signaling effects on the ...
However, there is still controversy about the role of TGF-β/SMAD in HCC. Because it involves different pathogenic factors, disease stages, and cell microenvironment, as well as upstream and downstream relationships with other signaling pathways. This review will summary the regulatory mechanism of ...
cells(P0.01) and the gene copies in T47 was middle.Conclusions: Our studies by FQ-PCR show that the lower TGF-βR1 and Smad4 mRNAs expression,the worse biology characteristic of breast cancer,which indicate TGF-βR1 and Smad4 act possibly as the role of anti-oncogene in breast cancer. ...
The seemingly opposite TGF-β action in cancer is appreciated as the ‘TGF-β paradox.’ This review first summarizes the basic knowledge of TGF-β signaling and then focuses on the dichotomous role of TGF-β in regulating cell survival and proliferation in liver cancer, underpinning the ...
The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer and survival, is helping to define the fragile areas where malignancies are likely to develop and shows promise for the development of better cancer therapi... Lopa,Mishra,Kirti,... - 《Oncogene》 被引量: 314发...
Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless...
Transforming growth factor-β (TGFβ) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host–tumour cell interactions. Studies of tumour-cell-autonomous TGFβ effects show clearly that TGFβ signalling has a mechanistic role in tumour suppressio...
The role of the TGF-β signaling pathway in cancer is significantly influenced by the stage of tumor development. In the early stages, this pathway functions as a tumor suppressor by inducing apoptosis in cancer cells, thereby inhibiting further tumor progression. As cancer advances, the TGF-β ...
The transforming growth factor-β (TGFβ) signalling pathway is implicated in a variety of disorders, including cancer, fibrosis and inflammation, and has become an attractive target for drug development. Here, Akhurst and Hata present therapeutic strate
and non cancer embolus types.The same result was detected in high differetial MHC tissue.These three indexes had obvious relationship in PHC between each other.Conclusion The expression of Smad4 TGF β 1 and TGF β R 1 have significant relationship to the important clinical characters of ...