Targeting TGF-beta Signaling in Cancer. Trends. Cancer 2017, 3, 56-71. [CrossRef] [PubMed]Colak, S.; Ten Dijke, P. Targeting TGF-β Signaling in Cancer. Trends Cancer 2017, 3, 56-71. [CrossRef] [PubMed]Colak, Selcuk, and Peter ten Dijke. 2017. "Targeting TGF-β Signaling in ...
The transforming growth factor-β (TGF-β) signaling pathway has a pivotal role in tumor suppression and yet, paradoxically, in tumor promotion. Functional context dependent insights into the TGF-β pathway are crucial in developing TGF-β-based therapeutics for cancer. AREAS COVERED This review ...
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis. The role of TGF-β in fibrosis and cancer is complex and sometimes even contradictory, exhibiting e...
TGFβ signaling has attracted the interest of cancer biologists because of its numerous roles in regulating cancer cell functions, including cell cycle progression, apoptosis, adhesion, and differentiation.3,15The biphasic functions of TGFβ during cancer progression on tumor cells and other cells in ...
TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matter of debate, due to its differential effects at the early and late stages of carcinogenesis. In contrast, at the ...
Nacif M, Shaker O. Targeting Transforming Growth Factor-β (TGF-β) in Cancer and Non-Neoplastic Diseases. J Cancer Ther. 2014;05(07):735- 47. doi: 10.4236/jct.2014.57082.M. Nacif, O. Shaker, Targeting transforming growth factor-β (TGF-β) in cancer and non-neoplastic diseases, J. ...
cancer patients.However,the critical function of TGFβin maintaining tissue homeostasis makes targeting TGFβa challenge.Here,we review the pleiotropic functions of TGFβin cancer initiation and progression,summarize the recent clinical advancements regarding TGFβ signaling interventions for cancer treatment...
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine, secreted by a variety of cells including immune cells, tumor cells, and stromal cells. TGF-β signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of...
Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless...
this signaling cascade to induce apoptosis [40,48]. In addition, it is also reported to promote TGFβ signaling in UV-exposed epidermal cells but TGFβ expression is down-regulated after myricetin treatment in the parasite-infected liver of mice [31,71]. Thus, the current review aims to ...