Trends in CancerColak, S.; Ten Dijke, P. Targeting TGF-beta Signaling in Cancer. Trends. Cancer 2017, 3, 56-71. [CrossRef] [PubMed]Colak, S.; Ten Dijke, P. Targeting TGF-β Signaling in Cancer. Trends Cancer 2017, 3, 56-71. [CrossRef] [PubMed]...
TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matter of debate, due to its differential effects at the early and late stages of carcinogenesis. In contrast, at the ...
10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cance...
Thus, TGF beta is a potent immunosuppressor, and perturbation of TGF beta signaling is linked to autoimmunity, inflammation, and cancer (1). Cell proliferation in somatic tissues, specification of cell fate during embryogenesis, differentiation, and cell ...
TGF-beta/SMAD/GLI2 signaling axis in cancer progression and metastasisThe Hedgehog (HH) and TGF-β signaling pathways representessential regulators of cell proliferation and differentiationduring embryogenesis. Pathway deregulation is a characteristicof various cancers. Recently, evidence for a convergence ...
10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. 11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230. 12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal c...
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer. 2010;10:415–24. CAS PubMed Google Scholar Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005;21:659–93. CAS PubMed Google Scholar Newman DJ, ...
10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. 11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230. 12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in...
1.Massagué J. TGFbeta in Cancer.Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. PMID:18662538; PMCID: PMC3512574. 2.Vander Ark A, et al. TGF-βreceptors: In and beyond TGF-β signaling. Cell Signal. 2018 Dec;52:112-120.doi: 10.1016/j.cellsig.2018.09.002...
The autocrine and paracrine effects of TGF-beta on tumor cells and the tumor micro-environment exert both positive and negative influences on cancer development. Accordingly, the TGF-beta signaling pathway has been considered as both a tumor suppressor pathway and a promoter of tumor progression and...