TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982.7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8(9):960. Published 2019 Aug...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19...
转化生长因子 (Transforming growth factor beta,TGF-β) 是一类多功能的细胞因子,可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子,与相应的受体、细胞内信号转导分子组成的通路,能影响疾病发生和发展,调节基因的转录,控制着细胞周期,影响细胞的增殖、分化、黏附、转移和凋亡。值得注意的是,TGF...
SRI-011381 hydrochloride :具有口服生物活性的 TGF-beta 信号通路的激活剂,具有神经保护作用。 TGF-beta/Smad 化合物库:100+ 种 TGF-β/SMAD 信号相关小分子化合物,是 TGF-β/SMAD 信号通路相关药物筛选和疾病研究的有用工具。 TGF-β 受体抑制剂/激动剂:TGF-β 受体是单通道丝氨酸/苏氨酸激酶受体,TGF-β ...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...
转化生长因子 (Transforming growth factor beta,TGF-β) 是一类多功能的细胞因子,可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子,与相应的受体、细胞内信号转导分子组成的通路,能影响疾病发生和发展,调节基因的转录,控制着细胞周期,影响细胞的增殖、分化、黏附、转移和凋亡。值得注意的是,TGF...
Alternatively, Smad1 and Smad5 can be activated by TGF-beta signaling in some cell types depending on the type I receptor that is expressed. Activated Smad proteins associate with Smad4 and translocate to the nucleus, where they recruit additional transcriptional regulators, including DNA-binding ...
转化生长因子 (Transforming growth factor beta,TGF-β) 是一类多功能的细胞因子,可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子,与相应的受体、细胞内信号转导分子组成的通路,能影响疾病发生和发展,调节基因的转录,控制着...