Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19:128-139. 18. Behringer RR, Finegold MJ, Cate RL. Mullerian-inhibiting substance function during mammalian sexual development. Cell 1994; 79:415-425.Zhang, Y. E. (2009) Non-Smad pathways in TGF-β signaling. Cell ...
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream ...
Non-Smad pathways in TGF-β signaling 来自 掌桥科研 喜欢 0 阅读量: 84 作者: Ying E Zhang 摘要: Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to reg-ulate a wide array of cellular functions.These non-canonical,non-Smad pathways are...
TGF-beta: an emerging player in drug resistance. Cell Cycle 2013; 12: 2960–2968. 11. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 2014; 15: 178–196. 12. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res ...
TGF-β Induces Sustained Upregulation of SNAI1 and SNAI2 through Smad and Non-Smad Pathways in a Human Corneal Epithelial Cell Line The aim of this study was to investigate the expression changes of epithelial mesenchymal transition (EMT)-related molecules induced by TGF-β signaling in... K ...
Transforming Growth Factor Beta (TGF-β) Fibrosis Focal Adhesion Kinase Non-Smad Introduction As a pleiotropic cytokine, TGF-β can regulate a variety of biological processes, including tissue growth, differentiation, cell migration, angiogenesis, and immunity (1). TGF-β signaling is initiated by ...
In injured liver, TGF-β affects all hepatic cell types and participates in wound healing and fibrogenesis. TGF-β downstream signaling is highly complex and cell type dependent, involving Smad and non-Smad signaling cascades thus requiring tight regulation. Endocytosis has gained relevance as importan...
Moustakas A, Heldin CH. Non-Smad TGF- signals. J Cell Sci 2005;118:3573-84.Non-Smad TGF-? signals. Aristidis Moustakas,Carl-Henrik Held. Journal of Cell Science . 2005Moustakas, A. & Heldin, C. H. Non-Smad TGF-[beta] signals. J. Cell Sci. 118, 3573-3584 (2005)....
One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of carcinogenesis. TGFβ/SMAD has been shown to dualist...
Jun Hwan Kim1, Jae Young Lee1, Yoe-Sik Bae1, Seung-Hoi Koo3, Seong-Jin Kim5 & Seok Hee Park1 Transforming growth factor (TGF)-b, a pivotal cytokine involved in a variety of cellular functions, transmits signals through Smad-dependent canonical and Smad-independent noncanonical pathways. ...