第一篇 TGF-β Signaling doi:10.3390/biom10030487 Activation of latent TGF-β. The TGF-β/SMAD signaling pathway. Internalization and intracellular sorting of TGF-β receptors. Schematic representation of structure of the SMAD proteins. The TGF-β non-SMAD signaling pathways. 第二篇 TGF-β rec...
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis. J Histochem Cytochem. 2016;64(3):157-167. doi:10.1369/0022155415627681 4. Meng XM, Tang PMK, Li J, Lan HY. TGF-ß/Smad signaling in renal fibrosis. Front Physiol. 2015;6(MAR):1-8. doi:10.3389/fphys.2015.00082...
2 Pathway regulation 2.1 Ligand agonists/antagonists 2.2 Receptor regulation 2.3 R-SMAD regulation 2.3.1 Role of inhibitory SMADs 2.3.2 R-SMAD ubiquitination 3 Summary table 4 External links 5 References [edit] Mechanism [edit]Ligand Binding The TGF Beta superfamily of ligands include:Bone morphogen...
Overview of TGF-beta/Smad The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. These proteins were identified mainly through their roles in development; they regulate the establishment of the body plan and tissue differentiation through their ...
germ.The pathogenesis of dental fluorosis has not been fully elucidated at present.TGF-β/Smad signaling pathway plays important roles in the regulatory mechanism of tooth germ development.TGF-β/Smad signaling pathway and its changes during development of dental fluorosis were reviewed in this ...
We desired to observe the changes of transforming growth factor-β1/drosophila mothers against decapentaplegic protein (TGF-β1/Smad3) signaling pathway in the hippocampus region of cerebral ischemic stroke rats so that the effects of this pathway on nerve cells can be investigated. The ischemic st...
Transforming growth factor beta (TGFβSmadSignaling pathwayModularizationStabilityThe transforming Growth Factor β (TGFβ) signaling pathway is a prominent regulatory signaling pathway controlling various important cellular processes. TGFβ signaling can be induced by several factors including ionizing radiation...
Positive and negative signals are equally critical for regulation of the TGF-β/Smad-signaling pathway (Massagué et al., 2005). Disruption of the balance between positive and negative regulation in TGF-β signaling can lead to various diseases (Massagué et al., 2000). We have herein present...
SMAD and non-SMAD pathways Schematic of the TGF-β-induced canonical SMAD and noncanonical non-SMAD signaling pathways MatureTGF-β phosphorylates TβR II, which recruits TβR I to phosphorylate receptor-SMAD proteins. TGF-β activated the Erk MAPK pathway. Essential functions of TGF-β in ...
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell., 16(4): 1987-... Valcourt U,Kowanetz M,Niimi H,... - 《Molecular Biology of the Cell》 被引量: 0发表: 2005年 TGF-β1 relieves epithelial–mesenchymal...