9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44.10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. ...
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis. J Histochem Cytochem. 2016;64(3):157-167. doi:10.1369/0022155415627681 4. Meng XM, Tang PMK, Li J, Lan HY. TGF-ß/Smad signaling in renal fibrosis. Front Physiol. 2015;6(MAR):1-8. doi:10.3389/fphys.2015.00082...
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982.7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8(9):960. Published 2019 Aug...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in ...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...
1 TGF β-Smad信号转导通路的分子组成 TGF β家族: TGF β是一个庞大家族群[1], 脊椎动物TGF β超家族包括TGF β、活动素(activin)和骨成型蛋白(bone morphogenetic proteins, BMPs); 哺乳动物TGF β共有三种: TGF β1、TGF β2和TGF β3, 其中肝脏含量最高且具有生物活性的是TGF β1, 由两条相同的...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...
目前研究最多的是亚型TGFβRⅠ-Ⅲ三种亚型,其中TGFβRⅠ(或称ALK5)和 TGFβ RⅡ是丝氨酸/苏氨酸蛋白激酶受体,参与TGF-β/Smad通路主要受体。TGFβ RⅢ是一种跨膜糖蛋白,不含激酶活性区,不直接参与 TGFβ/Smad信号,但在TGFβ与TGFβ RⅠ、TGFβ RⅡ结合中发挥辅助调节作用,促进TGFβ与受体的结合。 TGF...
TGF-beta/Smad PKC TGF-β Receptor Overview of TGF-beta/Smad The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. These proteins were identified mainly through their roles in development; they regulate the establishment of the body plan and...
TGF β 还诱导其他非 SMAD 信号转导通路,包括通过上游分子调节物 RhoA、Ras、TAK1(TGF β 激酶)、TAB1(TAK1 结合蛋白)和蛋白 XIAP(非洲爪蟾凋亡蛋白抑制因子)激活多个 MKK(MAP 激酶激酶)和MEK(MAPK/ERK 激酶)通路(JNK/SPAK、p38 和ERK1/2),HPK1(造血祖细胞激酶-1)...