TGF-βErkJNKp38RhoAAkt生长因子细胞内信号Transforming growth factor-尾 utilizes a multitude of intracellular signaling pathways in addition to Smads to reg-ulate a wide array of cellular functions.These non-canonical,non-Smad pathways are activated directly by ligand-occupied receptors to reinforce,atten...
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream ...
Non-Smad pathways in TGF-|[beta]| signaling 来自 NCBI 喜欢 0 阅读量: 322 作者: YE Zhang 摘要: 转变生长因素 -- 尾除了 Smads 利用大量的细胞内部的发信号小径调整细胞的功能的一个宽数组.这些不在经典中, non-Smad 小径被占据 ligand 的受体直接激活到增强,稀释,或不那样调制下游地细胞的回答.这些 ...
Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19: 128–139. LncRNA in epithelial–mesenchymal transition in cancer Q Xu et al 9 13. Yu L, Hebert MC, Zhang YE. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 2002; 21: 3749–...
ZHANG C,ZHANG X,XU R,et al.TGF-beta2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion[J/OL].J Exp Clin Cancer... C Zhang,X Zhang,R Xu,... 被引量: 0发表: 2018年 Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition Trans...
Moustakas A, Heldin CH (2005) Non-Smad TGF-b signals. J Cell Sci 118:3573-3584Moustakas A, Heldin CH (2005) Non-Smad TGFb signals. J Cell Sci 118: 3573-3584Moustakas, A. and Heldin, C.-H. (2005). Non-Smad TGF-b signals. J. Cell Sci. 118, 3573-3584....
Jun Hwan Kim1, Jae Young Lee1, Yoe-Sik Bae1, Seung-Hoi Koo3, Seong-Jin Kim5 & Seok Hee Park1 Transforming growth factor (TGF)-b, a pivotal cytokine involved in a variety of cellular functions, transmits signals through Smad-dependent canonical and Smad-independent noncanonical pathways. ...
In the context of cancer, TGF-² signaling can inhibit tumor growth in early-stage tumors. However, in late-stage tumors, the very same pathway promotes tumor invasiveness and metastasis. This paradoxical effect is mediated through similar to mothers against decapentaplegic or Smad protein ...
ZHANG C,ZHANG X,XU R,et al.TGF-beta2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion[J/OL].J Exp Clin Cancer Res,2017,36(1):162[2017-12-05].https://jeccr.biomedcentral.com/articles/10.1186/sl3046-017-0628-8....
We investigated the effects of TGF-beta(1) on the cellular functions of intestinal epithelial cells, and also evaluated its signaling pathways in these cells.We used the rat IEC-6 intestinal epithelial cell line for these studies. The expression of TGF-beta(1)/Smad signaling molecules was ...