Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated d
YE Zhang.Non-Smad pathways in TGF-beta signaling. Cell Research . 2009Zhang, Y. E. 2009. Non-Smad pathways in TGF-beta signaling. Cell Res. 19: 128-139.Zhang YE (2009) Non-Smad pathways in TGF-beta signaling. Cell Res 19: 128- 139.Zhang YE. Non-Smad pathways in TGF-beta ...
Y.E. Zhang Non-Smad pathways in TGF-beta signaling Cell Res., 19 (2009), pp. 128-139 CrossrefView in ScopusGoogle Scholar [11] M.C. Hall, D.A. Young, J.G. Waters, A.D. Rowan, A. Chantry, D.R. Edwards, I.M. Clark The comparative role of activator protein 1 and Smad fac...
The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating many physiological processes in development and tissue homeostasis. The TGF-β signaling pathway outcome relies on the control of the spatial and temporal expression of >500 genes, which depend on the funct...
Phosphorylated R-Smads accumulate in the nucleus as they make complexes with Smad4. In contrast, the I-Smads quench the activation of the pathway, thus fine-tuning TGFβ signaling [2, 5]. In addition to Smads, the TGFβ receptor complex activates alternative pathways, such as the mitogen-...
This is because the role of miRNA is nonspecific and acts as a cofactor instead of downstream effector in the signaling pathways involved.15 Since the discovery of Xist, a long non-coding RNA (lncRNA) required for mammalian X chromosome inactivation,16 many lncRNAs have been reported to play ...
(TGF—p1)和Smad2/3蛋白的表达;RT—PCR检测SnoNmRNA。结果 DM各组大鼠血糖和24h尿蛋白较正常对照组均显著升高;SnoN和Smad2/3 阳性染色主要见于肾小管上皮细胞,DM2w起Smad2/3和p-Smad3蛋白表达多于正常对照组,DM4w起SnoN蛋白少于正常对照组;各DM组肾组 ...
Zhang,Y.E. (2009) Non-Smad pathways in TGF-beta signaling. Cell Res., 19, 128-139.Zhang YE (2009) Non-Smad pathways in TGF-beta signaling. Cell Res 19:128-139Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009;19(1):128-39....
Non-Smad pathways in TGF-beta signaling. Cell Res 19: 128-139.Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009;19(1):128-39.Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19: 128-39.Zhang YE (2009) Non-Smad pathways in TGF-beta signaling. ...
The epithelial–mesenchymal transition (EMT), an essential event in embryonic development and tissue repair, has been implicated as a key process in initiation of metastasis [6]. Among the pathways known to induce EMT, transforming growth factor beta (TGF-β) signaling has been demonstrated as ...