Non-Smad pathways in TGF-beta signaling. YE Zhang. Cell Research . 2009Zhang YE, 2009. Non-Smad pathways in TGF-β signaling. Cell Res, 19(1):128-139. https://doi.org/10.1038/cr.2008.328Y.E. Zhang. Non-smad pathways in TGF-β signaling. Cell Res., 19(1):128-139, January 2009...
Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream ...
In addition to integrin-dependent FAK activation, FAK signaling is also evident for a number of growth factors, including TGF-β (24, 25, 34, 35, 36). Although in the majority of these cases PI3K/Akt represent downstream pathways whose activation is dependent upon FAK, there is relatively ...
We investigated the effects of TGF-beta(1) on the cellular functions of intestinal epithelial cells, and also evaluated its signaling pathways in these cells.We used the rat IEC-6 intestinal epithelial cell line for these studies. The expression of TGF-beta(1)/Smad signaling molecules was ...
Rabbit polyclonal primary antibodies were used against LC3B, SQSTM1, MMP2, MMP9, vimentin, N-cadherin, β-catenin, Slug2, Akt, JNK, SMAD2 (1:1000; Cell Signaling), TGF-β2 (1:500; Abcam), phospho-SMAD2, phospho-Akt, and phospho-JNK (1:500; Cell Signaling). Purified mouse anti-...
Aims/hypothesis The TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways have been shown to play a critical role in the d... S.,M.,Ka,... - 《Diabetologia》 被引量: 121发表: 2012年 TNFα represses BMP signaling by interfering with the DNA binding of smad...
Collectively, these results position Egr-1 downstream of c-Abl in the fibrotic response, delineate a novel Egr-1-dependent intracellular signaling mechanism that underlies the involvement of c-Abl in certain TGF-beta responses, and identify Egr-1 as a target of inhibition by imatinib. Furthermore...
Based on the exciting insights gleaned from decades of ground-breaking research, it has become evident that deregulated signaling pathways play instrumental role in cancer development and progression. Interestingly discovery of non-coding RNAs has revolutionized our understanding related to transcription, po...
Phosphorylated R-Smads accumulate in the nucleus as they make complexes with Smad4. In contrast, the I-Smads quench the activation of the pathway, thus fine-tuning TGFβ signaling [2, 5]. In addition to Smads, the TGFβ receptor complex activates alternative pathways, such as the mitogen-...
The epithelial–mesenchymal transition (EMT), an essential event in embryonic development and tissue repair, has been implicated as a key process in initiation of metastasis [6]. Among the pathways known to induce EMT, transforming growth factor beta (TGF-β) signaling has been demonstrated as ...