Transforming growth factor-beta (TGFbeta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host-tumour cell interactions. Studies of tumour-cell-autonomous TGFbeta effects show clearly that TGFbeta signalling has a mechanistic role in tumour ...
Roles of TGF-beta in Cancer Transforming growth factor-beta (TGF-beta) is a multifunctional regulatory polypeptide that is the prototypical member of a large family ofcytokinesthat controls many aspects of cellular function, including cellular proliferation, differentiation, migration, apoptosis, adhesion...
Transforming growth factor-beta (TGFbeta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host-tumour cell interactions. Studies of tumour-cell-autonomous TGFbeta effects show clearly that TGFbeta signalling has a mechanistic role in tumour sup...
TGFbeta in Cancer. Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review J Massagué - 《Cell》 被引量: 1.0万发表: 2008年 Mechanisms of TGF-beta signaling from cell membrane to the ...
摘要: Oncogene is one of the world's leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes.关键词:Smad metastasis fibrosis cancer signal transduction mesenchyme DOI: 10.1038/sj.onc.1208927 被引量: 3322 ...
However, at some point, its function can become out of control and become a tumor promoting factor, cultivating aggressive cell growth and promoting cancer spread. Purity (HPLC) ≥98.0% Single impurity≤2% Peptide content≥75.0% Amino Acid Composition≤±15% Bacterial Endotoxins≤50EU/mg ...
TGF-beta has mostly been researched in cancer cells. Its impact on cancer in humans is unknown. Remember that many substances and their related pathways have anti-cancer effects in cells. This doesn’t mean that they have any medical value. On the contrary, most pathways that are researched ...
Depending on the cancer type, versi... Carmela,Ricciardelli,Andrew,... - 《Cancer & Metastasis Reviews》 被引量: 284发表: 2009年 Function of TGF-beta2 in the growth of chicken primordial germ cells and germinal ridge stroma cells during embryonic development The development of chicken embryonic...
Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta.Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta...
TGF-β regulates both the tumor-forming and migratory abilities of various types of cancer cells. However, it is unclear how the loss of TGF-β signaling components affects these abilities in clear-cell renal cell carcinoma (ccRCC). In this study, we investigated the role of TGFBR3 (TGF-β...