Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to...
Physiology Myostatin and tgf-beta function in the regulation of myogenesis in rainbow trout (Oncorhynchus mykissa basal teleost UNIVERSITY OF RHODE ISLAND Terence M. Bradley JaffeIan MorrisonMyogenesis in vertebrates is a complex and intricately regulated process, various mechanisms of which have been ...
Cell Structure & FunctionMitaka, T.; Kojima, T.; Norioka, K., et al. TGF-β completely blocks the formation of small-cell colonies: effects of ... T Mitaka,T Kojima,KI Norioka,... - 《Cell Structure & Function》 被引量: 12发表: 1995年 Structural Symmetry and Protein Function Struc...
MAPKPPM1A15enternucleus•importin-α、β•Ras-familyGTPaseRan-GTP•Ran-GTP/CAScomplexnuclearexportfactor16cancer•CDK(G1arrest)•上皮间充质转化(EMT)17cancer•CDK(G1arrest)•上皮间充质转化(EMT)18Cell2006Jun2PPM1AFunctionsasaSmadPhosphatasetoTerminateTGFbSignaling19Cell2006Jun220Cell2016Feb...
TGF-beta1, -2, and -3 are a closely related group of proteins (70-80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta1, -2, and -3 are disulfide-linked homodimers. 仅用于科研。不用于诊断过程。未...
Therapeutic targeting of the TGF-beta pathway in tumors such as glioma, melanoma, and renal cell carcinoma is based on the rationale that TGF-beta exerts strong immunosuppressive effects in these tumors. Thus, blocking TGF-beta function might empower the immune system against the tumor. Blocking ...
TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis. BACKGROUND: Polymorphisms in transforming growth factor (TGF)-beta(1) associated with variations in cytokine levels are linked to fibrosis in a number of t... Arkwright,P. D - 《Thorax》 被引量:...
Among the negative regulators of SMAD function are two highly conserved members of the Ski family of proto-oncoproteins c-Ski and c-SnON that antagonizes TGF-Beta signaling through direct interactions with the SMAD2/SMAD3 and SMAD4 (Ref.6) and later degrade releasing SMADs to regulate ...
Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells. 展开 关键词: Tr1 - Th3 - CD4CD25 anergic/suppressor - IL-2 - CTLA-4 - Autoimmunity ...
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. T helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory diseases. ... L Zhou,JE Lopes,MM Chong,... - ...