具有口服生物活性的 TGF-beta 信号通路的激活剂，具有神经保护作用。TGF-beta/Smad 化合物库 100+ 种 TGF-β/SMAD 信号相关小分子化合物，是 TGF-β/SMAD 信号通路相关药物筛选和疾病研究的有用工具。TGF-β 受体抑制剂/激动剂 TGF-β 受体是单通道丝氨酸/苏氨酸激酶受体，TGF-β 超家族成员通过受体复合体发出...
研究表明,几乎所有细胞(包括大多数免疫细胞)均分泌潜在 TGFβ1(latent TGFβ1),TGF-β2主要表达在上皮细胞和神经细胞,TGFβ3则主要表达于间充质细胞。其中,TGFβ1 是表达最多的亚型,与多种疾病的发生、发展高度相关。 TGFβ家族蛋白前体的一级结构包括潜在相关蛋白(latencyassociated protein,LAP)、前体结构域(p...
Roberts. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998;16:137-61. 8. Akihiko Yoshimura, et al. TGF-β function in immune suppression. Curr Top Microbiol Immunol. 2011;350:127-47. 9. Andrew W Taylor. Review of the activation of TGF‐β in immunity. J Leukoc Biol...
Description:TGF-beta是由43个氨基酸组成的多肽,既是肿瘤促进因子,又是肿瘤抑制因子。TGF-beta是一种肿瘤抑制因子,它在对细胞进行审查、保持它们正常生长中是必不可少的,但在某个点上,它的功能会失控,变成了肿瘤促进因子,会培养细胞侵略式生长,助长癌症扩散。
Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated Proc. Natl. Acad. Sci. USA, 92 (1995), pp. 12215-12219 CrossrefView in ScopusGoogle Scholar Dumont and Arteaga, 2003 N. Dumont, C. Arteaga Targeting the TGFb signaling network in ...
Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells. 展开 关键词: Tr1 - Th3 - CD4CD25 anergic/suppressor - IL-2 - CTLA-4 - Autoimmunity ...
The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn’t been well-explored. Here we report that EZH2 promotes osteolytic metastasis of breast cancer through regulating transforming growth factor beta (TGFβ) ...
Transforming growth factor-beta (TGFbeta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host-tumour cell interactions. Studies of tumour-cell-autonomous TGFbeta effects show clearly that TGFbeta signalling has a mechanistic role in tumour sup...
Beta-type subfamily growth factors are homodimeric or heterodimeric polypeptides with multiple regulatory properties depending on cell type, growth conditions and presence of other polypeptide growth factors. Since their expression is also controlled by distinct promoters, their secretion is temporal and tis...
Description: The monoclonal antibody 1D11.16.8 recognizes human, mouse, rat, hamster, canine and non-human primate Transforming Growth Factor (TGF) beta 1, 2 and 3. TGF beta is a pleiotropic cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with ...