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Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to...
15、allMC,etal.TGF-betaactivatesErkMAPkinasesignallingthroughdirectphosphorylationofShcAJ.EMBOJ,2007,26(17):3957-3967.3 LinX,DuanX,Liang丫丫,etal.PPM1AFunctionsasaSmadPhosphatasetoTerminateTGF3SignalingJ.Cell,2006,125(5):915-928.4 MaBiao,ChengHongcheng,GaoRuize,etal.Zyxin-Siah2-Lats2axismediatescoope...
近日,山东大学齐鲁医院侯宇教授团队在国际血液学顶刊Blood(中科院一区Top,IF=20.3)在线发表题为“Platelet-derived TGF-β1 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia” 的研究论文,...
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invari
TGF- signalingandthefibroticresponseANDREWLEASK1ANDDAVIDJ.ABRAHAMCentreforRheumatology,DepartmentofMedicine,RoyalFree&UniversityCollegeMed..
Transforming growth factor-beta (TGFbeta) signalling regulates cancer through mechanisms that function either within the tumour cell itself or through host-tumour cell interactions. Studies of tumour-cell-autonomous TGFbeta effects show clearly that TGFbeta signalling has a mechanistic role in tumour sup...