Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression. Since the immune checkpoint pathways are co-opted in cancer to...
TGF beta-SMAD signal transduction: molecular specificity andfunctional flexibility J. Nat Rev Mol Cell Biol, 2007 23、, 8(12): 970 -982.16 Pinkas J, Teicher B A. Role of TGF- in Tumor Progression and Metastasis M. Cancer Drug Resistance. Humana Press, 2006: 469-489.17 Dobaczewski M, ...
TGF beta-SMAD signal transduction: molecular specificity andfunctional flexibility [J]. Nat Rev Mol Cell Biol, 2007, 8(12): 970 -982. [16] Pinkas J, Teicher B A. Role of TGF-β in Tumor Progression and Metastasis [M]. Cancer Drug Resistance. Humana Press, 2006: 469-489. [17] Do...
Molecular characterization of TGF beta-induced epithelial-mesenchymal transition in normal finite lifespan human mammary epithelial cells. Biochem Bioph Res Commun. 2010;399(4):659–64. Article CAS Google Scholar Giampieri S, Pinner S, Sahai E. Intravital imaging illuminates transforming growth ...
Regarding the canonical TGFβ pathway, active TGFβ initially binds to the low-affinity accessory TGFβ type III receptor (TβRIII), also named betaglycan, which is abundant on the surface of many cell types (Fig.3a). Betaglycan can present TGFβ to the TGFβ receptor complex, which is...
TGF-β signaling can inhibit cell growth in benign cells but promote cancerous biological behaviors in cancer cells; this phenomenon is known as the TGF-β paradox [8]. Paradoxical TGF-β functions are cell- and context-dependent with a specific molecular mechanism [9,10]. In benign cells, ...
英文名称:Recombinant Transforming Growth Factor Beta 2 (TGFb2) 分子式:电询 纯度:99 % 产地:进口/国产 品牌:钰博生物 包装规格:50ug 别名:电询 转化生长因子β2(TGFβ2)重组蛋白 FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
Transforming growth factor-beta (TGF-β) is extensively implicated in the pathogenesis of various types of fibrosis, including subretinal fibrosis, while TGF-β2 was shown to be more highly expressed than other TGF-β isoforms7,12,18,19. As a common mechanism of the mesenchymal transition ...
Haberstroh, U.et al. TGF-β stimulates rat mesangial cell proliferation in culture: role of PDGF beta-receptor expression.Am. J. Physiol.264, F199–F205 (1993). CASPubMedGoogle Scholar Wilson, H. M.et al. Effect of transforming growth factor-beta 1 on plasminogen activators and plasminogen...
TGF-beta signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation. Semin. Cell Dev. Biol. 32, 107–118 (2014). Article CAS PubMed Google Scholar Asagiri, M. & Takayanagi, H. The molecular understanding of osteoclast differentiation. Bone 40, 251–264 (...