RNA Seq profiling reveals a novel expression pattern of TGF-beta target genes in human blood eosinophils. Immunol Lett. 2015;167:1-10.Shen ZJ, Hu J, Esnault S, Dozmorov I, Malter JS, RNA Seq profiling reveals a novel expression pattern of TGF-beta target genes in human blood eosinophils...
Smad complexes translocate into the nucleus where they regulate the transcription of target genes, which contain one or more Smad binding elements (SBEs) in their promoter region [3]. Perturbations in TGF-β signaling affect immune homeostasis and tolerance, leading to inflammatory diseases and tumor...
Transforming growth factor beta (TGFβ), a multifunctional cytokine, plays a crucial role in the accumulation of extracellular matrix components in lung fibrosis, where lung fibroblasts are considered to play a major role. Even though the effects of TGFβ on the gene expression of several proteins...
It has been shown that SMAD4 restoration is associated with suppression of Wnt/β-catenin signaling activity, decrease of β-catenin/Tcf target genes expression and with induction of functional E-cadherin expression[223]. Recently, the role of microRNA in colon cancer has been established. ...
Overstreet, J. M., Samarakoon, R., Meldrum, K. K. & Higgins, P. J. Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.Cell. Signal.26, 1427–1436 (2014). CASPubMedPubMed CentralGoogle Scholar ...
Upstream regulatory genes were identified by IPA (Qiagen, Hilden, Germany) using all genes significantly enriched by MSC treatment compared to the control (P-value < 0.05) from the lung and liver. TGF-β1 target genes for both the liver and lung were plotted as regulatory network. ...
When we analyzed ATF1 and CREB expression, we found that both genes were induced by TGF-β, even in the presence of CHX (Figure 5D). The ability of TGF-β to induce expression of transcription factors that subsequently function as Smad partners to regulate other target genes is a ...
31. Yu Q, Stamenkovic I: Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000, 14:163–176. 32. Schultz-Cherry S, Murphy-Ullrich JE: Thrombospondin causes activation of latent transforming growth factor-beta...
2020 年6月,张欣欣教授在《Cell proliferation》杂志发表题名为“ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma.”——ITGBL1通过TGF-β信号通路促进肝癌细胞的...
(Supplementary Data1). Analysis of the transcriptomic dataset revealed that the relative expression levels of known TGFβ target genes (such asFibronectin,Lysyl oxidase, etc.) were strongly modulated by either treatment, while the expression levels of myogenic transcription factors (such asPax7,Myod1...