et al. Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res. 62, 4690–4695 (2002). CAS PubMed Google Scholar Dasch, J. R., Pace, D. R., Waegell, W., Inenaga, D. & Ellingsworth, L. Monoclonal antibodies recognizing transforming growth...
The TGF pathway has recently emerged as a putative therapeutic target against cancer. However, TGF has a complex and dual role in cancer. In normal epithelial cells and early tumours, TGF acts as a tumour suppressor. In contrast, during tumour progression TGF becomes an oncogenic factor inducing...
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcom...
20. SHAH R, HURLEY C K, POSCH P E. A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T)[J]. Hum Genet, 2006,120(4):461-469. 21...
Flavell Transforming growth factor beta in T cell biology Nat. Rev. Immunol., 2 (2002), pp. 46-53 CrossrefView in ScopusGoogle Scholar Hai and Hartman, 2001 T. Hai, M.G. Hartman The molecular biology and nomenclature of the activating transcription factor/cAMP-responsive element binding ...
Haberstroh, U.et al. TGF-β stimulates rat mesangial cell proliferation in culture: role of PDGF beta-receptor expression.Am. J. Physiol.264, F199–F205 (1993). CASPubMedGoogle Scholar Wilson, H. M.et al. Effect of transforming growth factor-beta 1 on plasminogen activators and plasminogen...
TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Chen, W, Frank, ME, Jin, W, Wahl, SM.TGF-β released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity. 2001. 14 :715-725... W Chen,Frank ME,Jin W,... - 《Immunity》 被引量:...
TGF-β signaling can inhibit cell growth in benign cells but promote cancerous biological behaviors in cancer cells; this phenomenon is known as the TGF-β paradox [8]. Paradoxical TGF-β functions are cell- and context-dependent with a specific molecular mechanism [9,10]. In benign cells, ...
TGF-beta/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29 TGF-β/Smad3 signaling promotes fibrosis, but the development of therapeutic interventions involving this pathway will require the identification and ultimate targeting of downstream fibrosis-specific genes. In this study, using a ...
et al. Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism. Proc. Natl Acad. Sci. USA 105, 2550–2555 (2008). Article ADS Google Scholar Takaku, S. et al. Blockade of TGF-β enhances tumor vaccine efficacy ...