在上皮细胞、组织成纤维细胞和免疫细胞中,TGF-β信号传导的缺陷会破坏免疫耐受,促进炎症,是纤维化和癌症发病机制的基础。 近日,美国加利福尼亚大学的Dean Sheppard教授在国际顶尖学术杂志《Cell》上发表了题为“TGF-β signaling in health and disease”的报道...
2023年9月14日,来自美国纪念斯隆凯特琳癌症中心Joan Massagué团队在《细胞》杂志上发表了标题为”TGF-β signaling in health and disease.“的研究成果,研究发现了TGF-β在健康和疾病中的信号传导。 据介绍,TGF-β调节系统在维持机体完整性方面发挥着至关重要的作用。 研究结果表明,TGF-β信号通过对共享生态系统...
Finally, cathepsin B regulated TGF-β production/signaling, which was required for the activation of fibroblasts and their promotion of the invasive growth of melanoma cells. These data provide a basis for testing inhibitors of TGF-β signaling and cathepsins B/L in the therapy of invasive/...
摘要: With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling ...关键词:TGF-β signaling SIK EMT polarity Notch ALK5 p21 growth arrest Smurf ...
Dendritic cells (DCs) mediate host immune responses to gut microbes and play critical roles in inflammatory bowel disease. In this study, we examined the role of TGF-β signaling in DCs in colonic homeostasis. CD11c-cre Tgfbr2(fl/fl) mice developed spontaneous colitis, and CD11c-cre Tgfbr2(...
Harris W T,,Kelly D R,Zhou Y,et al.Myofibroblast differentiation and enhanced TGF-B sinaling in cystic fibrosis lung disease. PLoS One . 2013Harris WT, Kelly DR, Zhou Y, et al. Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease. PLoS One. 2013;8(...
TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet. 29, 117–129 (2001). 66. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253–310 (1995). 67. Ning,...
Lonicera japonica;PM2.5;pulmonary disease;inflammation;fibrosis 1. Introduction Particulate matter (PM) in the air can penetrate the respiratory system and cause various adverse health effects [1]. When PM enters the body, it triggers an inflammatory response and cytotoxicity in lung tissue [2]. ...
TGF-beta1 functions as a negative regulator of T cell immune responses, signaling to target cells using the Smad family of proteins. We show here that Smad7, an inhibitor of TGF-beta1 signaling, is overexpressed in inflammatory bowel disease (IBD) mucosa and purified mucosal T cells. Both ...
Alternatively, it has been suggested that the inhibition of Cat S may disturb TGF-β1 signaling and impair the differentiation of fibroblasts in a murine model of myocardial infarction (21). Particularly, Cats production is increased in chronic lung disorders such as silicosis, asthma, and cystic...