M.A., Catalano, P.J., et al. (2021). Expression of T-Cell exhaustion molecules and human endogenous retroviruses as predictive biomarkers for response to nivolumab in metastatic clear cell renal cell carcinoma. Clin. Cancer Res.
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'.Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9 3. Jean-Christophe, Beltra., Sasikanth, Manne., Mohamed S...
RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity Article Open access 20 April 2022 MYB orchestrates T cell exhaustion and response to checkpoint inhibition Article Open access 17 August 2022 References Arce, L., Yokoyama, N. N. & Waterman, M. L. Diversit...
CD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol, 20(8), 0. doi:10.1038/s41577-020-0274-9 2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kalli...
proliferation8. Expression of the transcription factor T cell factor 1 (Tcf1, encoded byTcf7), is required for the formation of TCMcells25,26. Recently, an important role for Tcf1 was found in chronic lymphocytic choriomeningitis virus (LCMV) infection that induces T cell exhaustion, which is...
T cell exhaustionTcf1Exhausted CD8 T (Tex) cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts. A stem cell-like Tex (Tex-stem) subset can self-renew and differentiate into terminally exhausted (Tex-term) cells. Here, we show that ectopic ...
Braun, D.A., Wind-Rotolo, M., Sticco-Ivins, M.A., Catalano, P.J., et al. (2021). Expression of T-Cell exhaustion molecules and human endogenous retroviruses as predictive biomarkers for response to nivolumab in...
CD8 T cell exhaustionimmunotherapyTCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial ...
2. Christian U, Blank., W Nicholas, Haining., Werner, Held., Patrick G, Hogan., Axel, Kallies., Enrico, Lugli., et al. (2019). Defining 'T cell exhaustion'. Nat Rev Immunol, 19(11), 0. doi:10.1038/s41577-019-0221-9
T-cell factor 1 (Tcf-1) controls an essential step in thymocyte differentiation. Tcf-1 enables β-catenin to transduce Wnt signals by association with its monomer. It is closely related to lymphoid enhancer factor. The expression pattern of both genes is complex and largely overlapping during em...