因此,CD8+T细胞生物学动态与HIV感染患者息息相关。在慢性感染和肿瘤中,持续的抗原刺激诱导耗竭性T细胞(exhausted T cell,Tx)的产生【2】。TX的典型特征是由TOX等转录因子驱动的转录组和表观组重塑介导的效应功能减弱和抑制性受体...
CD8 T cell exhaustionimmunotherapyTCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial ...
T cell exhaustionTcf1Exhausted CD8 T (Tex) cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts. A stem cell-like Tex (Tex-stem) subset can self-renew and differentiate into terminally exhausted (Tex-term) cells. Here, we show that ectopic ...
瘤内干细胞样CD8+T细胞对于ICB反应至关重要，其效应依赖于T细胞因子1（TCF1；由Tcf7编码）的表达，研究表明消除CD8+T细胞中的Tcf7会限制ICB在癌症模型中的疗效【1】，表达TCF7的CD8+T细胞的频率与黑色素瘤患者对ICB的阳性反应相关【2】。然而，一些研究得到了不一致的结果，在接受ICB治疗的晚期透明细胞肾癌患者中...
J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. Rev. Immunol. 37, 457–495 (2019). Article CAS PubMed Google Scholar Paley, M. A. et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220–1225 (...
近日,来自哈佛医学院的Ana C. Anderson团队在Cancer Cell杂志上发表了一篇题为Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy的文章,他们发现CD8+T细胞中TCF1的表达对于低免疫原性肿瘤ICB...
近日,来自哈佛医学院的Ana C. Anderson团队在Cancer Cell杂志上发表了一篇题为Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy的文章,他们发现CD8+T细胞中TCF1的表达对于低免疫原性肿瘤ICB反应而言是必需的,对于高免疫原性肿瘤的T细胞启动和治疗反应则是可有可无的。通...
CD8+ T cells in tumors span a spectrum of functional states reflecting their stemness, memory potential, effector function, and dysfunction or exhaustion status, all of which are shaped by both cell-intrinsic regulation and the tumor microenvironment (TME). Harnessing the effector potential of these...
Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8+ T cells in the tumor microenvironme
在人类免疫缺陷病毒 (human immunodeficiency virus,HIV) 感染中,CD8+T细胞对于病毒的清除至关重要【1】(详见BioArt报道:) 。因此,CD8+T细胞生物学动态与HIV感染患者息息相关。在慢性感染和肿瘤中,持续的抗原刺激诱导耗竭性T细胞(exhausted T cell,Tx) 的产生【2】。TX的典型特征是由TOX等转录因子驱动的转录组和表...