agonists are hypothesized to overcome EGFR TKI resistance. Using human NSCLC cell models with PTEN deficiency, the potentiation of EGFR TKI anticancer activity by PPAR gamma agonists was evaluated. PPAR gamma agonists were found to upregulate PTEN, subsequently inhibiting the PI3K-Akt signaling pathway...
The effect is independent of insulin effects and could only be partially due to lipid effects. These renal protective effects of PPAR-gamma agonists suggest that they may provide a novel intervention strategy to prevent vascular and glomerular sclerosis. 展开 被引量: 40 年份: 2005 ...
PPAR-gamma agonists decrease hyperhomcysteinemia and cardiac dysfunction: new hope for ailing diabetic hearts? 来自 NCBI 喜欢 0 阅读量: 39 作者:RB Rezk,PA Lucchesi 摘要: The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) family of nuclear hormone receptors has been extensively ...
INT131 described in U.S. Pat. No. 7,601,841. INT131 is unique among PPARγ agonists in that it is a selective activator of a highly limited number of PPARγ pathways. Among these INT131-sensitive pathways are metabolic pathways including those pathways regulated by the hormone adiponectin....
Modulation of the oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion Agonists of the peroxisome proliferator-activated receptor-γ (PPAR-γ) exert protective effects in several models of ischemia/reperfusion injury, but thei...
Our results demonstrate that PPARgamma mRNA is expressed in ECV304 cells, and transfected cells with a PPARE luciferase construct respond to these agonists. In addition, ligand-dependent PPARgamma activation increased ICAM-1 protein expression and enhanced adherence of monocytes to ECV304 cells by ...
PPAR-gamma agonists, the... SZ Duan,MG Usher,RM Mortensen - 《Circulation Research》 被引量: 499发表: 2008年 Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of indu... Cerebellar granule cells (CGCs)...
PPAR-gamma agonists as agents for the treatment of type II diabetes 发明人: KOLB HARTMUTH C.;MCGEEHAN GERARD;SHI ZHI-CAI;KOLLA LAXMA REDDY;CAVALLARO CULLEN 申请人: 申请日期: 2000-04-18 申请公布日期: 2004-03-30 代理机构: 代理人: 地址: 摘要: N-(substituted)carbamoylaryl- and heter...
Sato, H, Ishihara, S, Kawashima, K (2000) Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPAR gamma agonists. Brit J Can 83: pp. 1394-1400摇Sato H,Ishihara S,Kawashima K,et al. Expression of Per鄄 oxisome proliferator鄄...
PPAR gamma agonists were reported to decrease inflammation in the brain by lowering the phosphorylation of JAK 1, 2, STAT 1, and 3 phosphorylation and rapidly promoting SOCS 1 and 3 in activated astrocytes and microglial cells [36]. An endogenous PPAR gamma ligand, 15d-PGJ2, has been shown...