(Tam) in luminal A breast cancer (BC) cells. Furthermore, it focuses on evaluating the possibility of repurposing Imatinib mesylate, an FDA-approved anticancer agent recently recognized also as a PPARγ antagonist, for the personalized therapy of endocrine-resistant BC with increased PPARγ ...
Wuhan Integrated TCM & Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Aim: To study the probable mechanisms of the anti-glomerulosclerosis effects induced by peroxisome proliferator-activated receptor gamma (PPARγ) agonists in rat in...
PPARG A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, an...
The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms. Anticancer Res. 2011;31:813–23. CAS PubMed Google Scholar Al-Jameel W, Gou X, Forootan SS, Al Fayi MS, Rudland PS, Forootan FS, et al. ...
SMITH Stephen Alistair
产品编号:516566-50MG查看说明书 产品名称:PPARGAMMA ANTAGONIST III, G3335 .0订购此产品 供应商:Merck 规格:*** 目录价:1182 库存状态:3周到货 CAS编号:36099-95-3 应用范围:生化实验 种属来源: 相关信息: PPARγ Antagonist III, G3335 A cell-permeable dipeptide that acts as a selective and reversible...
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A dominant-negative PPARgamma partially reversed the inhibition of myofibroblast differentiation by 15d-PGJ2 and rosiglitazone, but the irreversible PPARgamma antagonist GW-9662 did not, suggesting that the antifibrotic effects of the PPARgamma agonists are mediated through both PPARgamma-dependent and ...
there are three different directional H-bonds between hydroxyl at His449, Met364 and Cys285. These H-bonds enhance the binding stability. The specific interaction of PPT with PPAR-gamma LBD is also displayed in a 2D-interaction map (Fig. 6f). Collectively, PPT is a novel antagonist of PPAR...
The researchers note that imatinib blocks CDK5-mediated PPARγ phosphorylation acting as a PPARγ antagonist ligand. Imatinib improvedinsulin sensitivityin high fat-fed mice, without causing severe side effects associated with other PPARγ-targeting drugs. Imatinib was also found to reduce lipogenic and...