agonists are hypothesized to overcome EGFR TKI resistance. Using human NSCLC cell models with PTEN deficiency, the potentiation of EGFR TKI anticancer activity by PPAR gamma agonists was evaluated. PPAR gamma agonists were found to upregulate PTEN, subsequently inhibiting the PI3K-Akt signaling pathway...
PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer by Sangeeta Ballav, Bini Biswas, Vishal Kumar Sahu, Amit Ranjan * and Soumya Basu * Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Pati...
INT131 (also known as CHS-131) is a novel, first-in-class, selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). The PPARγ is a transcription factor belonging to the steroid/thyroid/retinoid receptor superfamily. To date, PPARγ agonists have been therapeutic agents ...
PPAR-gamma agonists decrease hyperhomcysteinemia and cardiac dysfunction: new hope for ailing diabetic hearts? 来自 NCBI 喜欢 0 阅读量: 39 作者:RB Rezk,PA Lucchesi 摘要: The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) family of nuclear hormone receptors has been extensively ...
Previously, the present authors have shown that PPAR-gamma agonists inhibit the release of inflammatory cell survival factors and induce apoptosis in vitro. The aim of this study was to determine the effect of two structurally different...
Agonists of the peroxisome proliferator-activated receptor-γ (PPAR-γ) exert protective effects in several models of ischemia/reperfusion injury, but thei... Massimo Collino a,Manuela Aragno b,Raffaella Mastrocola c,... - 《European Journal of Pharmacology》 被引量: 603发表: 2006年 The effects...
Peroxisome proliferator-activated receptor (PPAR) agonists improve glucose control and insulin sensitivity, reduce concentrations of atherogenic lipoproteins, and decrease circulating levels of inflammatory mediators. PPAR activation is considered an important pharmacologic target for patients with type 2 diabetes...
Which PPAR gamma adjustable fat cells divide and promote lipid and energy storage. PPAR AT 1R gamma can affect the booster role of further infer AT 1R expressed by suppressing the PPAR gamma agonists may regulate II angiotensin induced vascular smooth muscle cell proliferation and hyperplasia. There...
PPAR-gamma agonists as agents for the treatment of type II diabetes 发明人: KOLB HARTMUTH C.;MCGEEHAN GERARD;SHI ZHI-CAI;KOLLA LAXMA REDDY;CAVALLARO CULLEN 申请人: 申请日期: 2000-04-18 申请公布日期: 2004-03-30 代理机构: 代理人: 地址: 摘要: N-(substituted)carbamoylaryl- and heter...
Evidence for peroxisome proliferator-activated receptor (PPAR)alpha-independent peroxisome proliferation: effects of PPARgamma/delta-specific agonists in P... Peroxisome proliferators are a diverse group of compounds that cause hepatic hypertrophy and hyperplasia, increase peroxisome number, and on chronic ...