PPAR[alpha] Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance[double dagger]Klaunig, James EBabich, Michael ABaetcke, Karl PCook, Jon CEt al
Agonist binding unmasks lysine 358 in the LBD for SUMOylation, hence conferring repressive activity to PPARα [22]. Table 1. Functional analysis of PPARα structural domains. PPARα displays a classical NR canonical architecture. PPARα domains (from A to F) fulfil distinct functions by ...
Peroxisome Proliferator-activated Receptor α (PPARα) Agonist Treatment Reverses PPARα Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethan... Proper function of the peroxisome proliferator-activated receptor alpha (PPARalpha) is essential for the regulation of hepatic fatty acid metabolism...
A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR{gamma}) Recruits PPAR{gamma}-Coactivator-1{alpha}, Prevents Triglyceride ... B Elke,S Astride,F Angele,... - 《Molecular Endocrinology》 被引量: 243发表: 2006年 A novel insulin sensitizer acts as a coligand...
a novel PPAR (Peroxisome proliferator - activated receptor) alpha/ gamma agonist to improve insulin resistance and dyslipidemia in MSG obese rats and hyperglycemia in diabetic KKA - y mice.METHORDS: KKA- y mice were divided into three groups that received chiglitazar (20 mg kg - 1 day - 1)...
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family Structure (2001) K.M. Darwish et al. Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARgamma/FFAR1 dual agonists Eur. J...
USE OF A PPAR-ALPHA AGONIST AND METFORMIN FOR THE TREATMENT OF OBESITYThe present invention relates to the combined use of a PPARalpha agonist and metformin for decreasing serum triglycerides.doi:EP1569634 B1JUNIEN Jean-LouisEDGAR AlanCHAPUT Evelyne...
Possible role of intestinal fatty acid oxidation in the eating-inhibitory effect of the PPAR-alpha agonist Wy-14643 in high-fat diet fed rats. PLoS One 8, e74869 (2013). Article ADS PubMed PubMed Central Google Scholar Bunger, M. et al. Genome-wide analysis of PPARalpha activation in ...
Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages[J].Experimental Cell Research,2008,(18):3405-3414.doi:10.1016/j.yexcr.2008.09.002.Souissi IJ, Billiet L, Cuaz-Perolin C, Slimane MN, Rouis M (2008) Matrix metalloproteinase-12 gene ...
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARgamma) and alpha (PPARalpha), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.HAN, HEE OON...